Latest Headlines
Age should not affect chemotherapy choice for stage IV lung cancer: guidelines
Early PET-CT predicts treatment response of head and neck cancer
Evidence scarce to support RF ablation of colorectal CA metastases in the liver
Casopitant helps curb chemotherapy emesis
Australian scientists plan to regrow breasts after cancer
NEWS PROVIDED BY 
VIEW ALL NEWSAspirin cuts recurrence of superficial bladder cancer
NEW YORK (Reuters Health) - The use of aspirin as a cardioprotective agent significantly reduces recurrence among patients being treated for high-grade, non-muscle-invasive bladder cancer, the results of a small case-control study suggest.
The subgroup of patients with carcinoma in situ and high-grade papillary bladder cancer has a "high risk of tumour recurrence and progression and thus represents an ideal cohort for evaluating chemopreventive agents," the research team, led by Dr. Jason R. Gee at the University of Wisconsin-Madison, comments in the March issue of BJU International.
Their study cohort comprised 43 such patients treated with intravesical bacille Calmette-Guerin. Twenty were taking aspirin (81 or 325 mg/day) for cardioprotection.
The 5-year recurrence-free survival rate was 64.3% among those taking aspirin versus 26.9% among those not taking aspirin (p = 0.03). After adjusting for multiple confounders, aspirin correlated with a significant effect on recurrence rate (hazard ratio 0.179, p = 0.001).
Other independent predictors were maintenance treatment with intravesical bacille Calmette-Guerin (HR 0.233, p = 0.02) and smoking history (HR 3.199, p = 0.05).
"The results of the present study support the further investigation of aspirin and other NSAIDs as preventive agents in patients being treated for non-muscle-invasive bladder cancer," Dr. Gee and associates conclude.
Copyright © 2009 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.
NEWS PROVIDED BY
TEXT SIZE 