To help patients and loved ones affected by a diagnosis of colon cancer establish a plan for moving forward, CURE Connections® program host Philippa Cheetham, MD; oncologist John Marshall, MD, (Georgetown Lombardi Comprehensive Cancer Center); surgeon Mohammed Bayasi, MD, (MedStar Georgetown University Hospital); and a patient, Jody Olsen, PhD, MSW, highlight top considerations for starting the journey. The panelists provide advice to help others prepare for important medical appointments with healthcare professionals, discuss what to expect before and after surgery, and remark on the value of support that different members of a patient’s care team (eg, health care professionals, family members, and the caregiver) can offer to patients.