Would you have any information about new protocols for high risk APL patients? There seems to be a lot of different approaches. Here in Canada I have to do 2 yrs of maintenance involving ATRA, methotrexate and mercaptapurine, yet I know some people in US or abroad who had different maintenances or none at all. Has there been more research done on whether maintenance is needed for high risk- I would love to avoid taking more chemo meds that have not nice side effects and possible secondary cancers related to them. Thank you!