I was surprised to see no mention of the prescription drug Vagifem in this article. None of the suggestions in this article for vaginal dryness worked for me. When Vagifem came on the market a few years ago, my oncologist prescribed it for me. It has been magical. My cancer was estrogen receptor positive and I couldn't use hormone therapy. I'm not even allowed to eat soy. But Vagifem has been shown to not stray outside the walls of the vagina. It's somewhat expensive, $30 a month on my prescription plan. But it gave me a pre-menopausal vagina back.