PROBLEM: Not all cancer cells can be induced to undergo apoptosis (programmed cell death). Even when they do, the mere act of apoptosis can trigger the proliferation of cancer stem cells. Cancer stem cells can lead to distant metastasis, treatment failure, and disease recurrence.
SOLUTION: Target cancer stem cells by directly killing them and/or preventing them from entering a dormant and more resistant state.
PROBLEM: Instead of apoptosis, some cancer cells can be induced to enter a senescent or dormant state. Fortunately, senescent cancer cells permanently stop dividing, but unfortunately, they don