Web Exclusive: Clinical Trials for CUP

A listing of clinical trials for patients with cancers of unknown primary are listed below.  


Therapy: Treatment based on molecular profiling assay – paclitaxel, carboplatin, bevacizumab, erlotinib
Cancer: Carcinoma of Unknown Primary
Phase: II
Sponsor/Manufacturer: Sarah Cannon Research Institute/Genentech
Contact information: John D. Hainsworth, MD, 615-329-7274;

Therapy: Avastin (bevacizumab)
Cancer: Neuroendocrine Carcinoma
Phase: III
Sponsor/Manufacturer: Southwest Oncology Group, National Cancer Institute
Contact information: James Yao, MD, 713-792-2828; or 800-392-1611

Therapy: Taxotere (docetaxel), 5-FU (5-fluorouracil), Platinol (cisplatin)
Cancer: Squamous Cell or Undifferentiated Carcinoma
Phase: II
Sponsor/Manufacturer: M.D. Anderson Cancer Center/Sanofi-Aventis
Contact information: Ehab Y. Hanna, MD, 713-745-2672;

Therapy: Xeloda (capecitabine)
Cancer: Solid Tumors and Adenocarcinoma of Unknown Primary
Phase: I/II
Sponsor/Manufacturer: Ohio State University Comprehensive Cancer Center
Contact information: OSU Cancer Clinical Trial Matching Service – 866-627-7616;

Therapy: Vectibix (panitumumab)
Cancer: Squamous Cell Carcinoma of the Head and Neck; Undifferentiated Carcinoma; Adenosquamous Cell Carcinoma
Phase: I
Sponsor/Manufacturer: Dana-Farber Cancer Institute; Brigham and Women’s Hospital; Massachusetts General Hospital/Amgen
Contact information: Lori J. Wirth, MD, 617-632-3090;

Therapy: Nexavar (sorafenib)
Cancer: Advanced Solid Tumors
Phase: II
Sponsor/Manufacturer: University of California Davis
Contact information: UC Davis Clinical Trials Office – 916-734-3089 or Primo N. Lara, MD, 916-734-3772;

Therapy: Stereotactic Body Radiotherapy
Cancer: Spinal Neoplasms
Phase: I/II
Sponsor/Manufacturer: M.D. Anderson Cancer Center
Contact information: Eric L. Chang, MD, 713-563-2300; 


Investigators in clinical trials may be individual physicians, researchers at institutions, or pharmaceutical company representatives. The contact information given here was provided by those running these trials and was accurate at the time of publication. If you get a voice mail, leave the pertinent information. For additional trials, go to

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