Blog: A do-it-yourself treatment program for cancer survivors
March 22, 2011
Blog: Hair, Glorious Hair
March 22, 2011 – Kathy LaTour
Words of Wisdom
March 21, 2011
Chilling Hair News
March 21, 2011 – Kathy LaTour
Videos from Yoga Bear
March 21, 2011
JourneyForward.org
March 16, 2011 – Elizabeth Whittington
Herb Could Work Against Advanced Breast Cancer
March 16, 2011 – Kathy LaTour
Transplants More Effective for Young Adults with AML
March 15, 2011 – Elizabeth Whittington
Predicting Colorectal Cancer Recurrence
March 15, 2011 – Elizabeth Whittington
Yoga by Any Other Name
March 03, 2011
Cancer: The Change I Cherish
March 11, 2011
CA-125: What the Numbers Tell Us
March 03, 2011 – Lindsay Ray
Origins of Ovarian Cancer
March 03, 2011 – Renée Twombly
A Primer on How Faster Approval Works
March 03, 2011 – Mike King
Reclaim Your Brain
March 03, 2011 – Staff Reports
The Legal Side of Chemobrain
March 03, 2011 – Kathy LaTour
Mining Cancer Data in the Molecular Age
March 03, 2011 – Mike King
Expecting the Unexpected
March 03, 2011 – Don Vaughan
Bending the Rules
March 03, 2011 – Claudia M. Caruana
Sifting
March 03, 2011 – Janet Filips
The Emperor of All Maladies: A Biography of Cancer
March 03, 2011 – Kathy LaTour
Q & A: Medicare and Advance Care Planning
March 03, 2011 – Len Lichtenfeld, MD
Know Your Rights
March 03, 2011
Favre Visits Pediatric Patient
March 03, 2011 – Lindsay Ray
Jumping on the Ban Wagon
March 03, 2011 – Lindsay Ray
Pipeline
March 03, 2011 – Staff Reports
The Fragile Bonds of Cancer
March 02, 2011 – Richard C. Frank
The Machine and Me
March 02, 2011 – Ginny Vroblesky
A Mouth Full
March 02, 2011 – Lacey Meyer
Overhauling Clinical Trials
March 02, 2011 – Laura Beil
Hitting Hard-to-Treat Cancers
March 02, 2011 – Mike King
Fighting Back
March 02, 2011 – Lindsay Ray
Letters From Our Readers
March 14, 2011
What is the Benefit, Precisely?
March 02, 2011 – Debu Tripathy, MD
Breaking Out of the Silence
March 02, 2011 – Renée Twombly
Hurdles on the Faster Track
March 02, 2011 – Mike King
Lifting the Fog on Chemobrain
March 02, 2011 – Elaine Schattner, MD
Blog: A do-it-yourself treatment program for cancer survivors
March 22, 2011
Blog: Hair, Glorious Hair
March 22, 2011 – Kathy LaTour
Words of Wisdom
March 21, 2011
Chilling Hair News
March 21, 2011 – Kathy LaTour
Videos from Yoga Bear
March 21, 2011
JourneyForward.org
March 16, 2011 – Elizabeth Whittington
Herb Could Work Against Advanced Breast Cancer
March 16, 2011 – Kathy LaTour
Currently Viewing
Transplants More Effective for Young Adults with AML
March 15, 2011 – Elizabeth Whittington
Yoga by Any Other Name
March 03, 2011
Cancer: The Change I Cherish
March 11, 2011
CA-125: What the Numbers Tell Us
March 03, 2011 – Lindsay Ray
Origins of Ovarian Cancer
March 03, 2011 – Renée Twombly
A Primer on How Faster Approval Works
March 03, 2011 – Mike King
Reclaim Your Brain
March 03, 2011 – Staff Reports
The Legal Side of Chemobrain
March 03, 2011 – Kathy LaTour
Mining Cancer Data in the Molecular Age
March 03, 2011 – Mike King
Expecting the Unexpected
March 03, 2011 – Don Vaughan
Bending the Rules
March 03, 2011 – Claudia M. Caruana
Sifting
March 03, 2011 – Janet Filips
The Emperor of All Maladies: A Biography of Cancer
March 03, 2011 – Kathy LaTour
Q & A: Medicare and Advance Care Planning
March 03, 2011 – Len Lichtenfeld, MD
Know Your Rights
March 03, 2011
Favre Visits Pediatric Patient
March 03, 2011 – Lindsay Ray
Jumping on the Ban Wagon
March 03, 2011 – Lindsay Ray
Pipeline
March 03, 2011 – Staff Reports
The Fragile Bonds of Cancer
March 02, 2011 – Richard C. Frank
The Machine and Me
March 02, 2011 – Ginny Vroblesky
A Mouth Full
March 02, 2011 – Lacey Meyer
Overhauling Clinical Trials
March 02, 2011 – Laura Beil
Hitting Hard-to-Treat Cancers
March 02, 2011 – Mike King
Fighting Back
March 02, 2011 – Lindsay Ray
Letters From Our Readers
March 14, 2011
What is the Benefit, Precisely?
March 02, 2011 – Debu Tripathy, MD
Breaking Out of the Silence
March 02, 2011 – Renée Twombly
Hurdles on the Faster Track
March 02, 2011 – Mike King
Lifting the Fog on Chemobrain
March 02, 2011 – Elaine Schattner, MD

Transplants More Effective for Young Adults with AML

Adolescents with AML tend to do better with stem cell transplant.

BY Elizabeth Whittington
PUBLISHED March 15, 2011

While acute myeloid leukemia affects all age groups, treatment differs for pediatric patients compared with older adults. The question, though, is how to treat newly diagnosed adolescents and young adults—with the intensive childhood regimen of high-dose chemotherapy and an allogeneic transplant (when the patient receives donor stem cells after high-dose chemotherapy has killed off the cancer cells and healthy stem cells) or the more mild adult regimen of autologous transplant (when the patient is re-infused with stem cells from his or her own body that were collected before chemotherapy)?

Researchers from a multi-center trial retrospectively examined outcomes in 517 patients, ages 16 to 21 years, with AML who were treated between 1986 and 2008. Of the 13 trials examined, five were conducted by the Childhood Oncology Group (COG), which treated patients with an allogeneic transplant, whereas the remaining eight trials, conducted by two adult oncology cooperative groups, Southwest Oncology Group (SWOG) and Cancer and Leukemia Group B 3 (CALGB3), treated patients with autologous transplants.

At 10 years, there was a clear difference in overall survival favoring the COG-treated patients (45 percent versus 36 percent). While the study only examined patients with an age range of six years, researchers noticed a marked difference among the younger patients (16 to 18 years) and older patients (19 to 21 years) in the studies. It was noted that younger patients had a 43 percent 10-year survival rate compared with 32 percent for patients. The risk of relapse was also lower in the COG studies. One negative, however, was higher rate of treatment-related deaths in the COG studies compared with the CALGB3 and SWOG studies.

Be the first to discuss this article on CURE's forum. >>
Talk about this article with other patients, caregivers, and advocates in the Leukemia CURE discussion group.

Related Articles

1
×

Sign In

Not a member? Sign up now!
×

Sign Up

Are you a member? Please Log In