Taking It Personally
March 07, 2014 – Laura Beil
Advocacy in Action
March 08, 2014 – Jane Hill
Can a Pill Prevent Cancer?
March 08, 2014 – Erik Ness
New Requirements for Patients and Survivors Needs
March 08, 2014 – Katy Human
How Survivors Can Take Action
March 08, 2014
Promises to Keep
March 06, 2014 – Tracy Stewart
Aiming to Improve Quality of Cancer Care
March 06, 2014 – Shelley Fuld Nasso
Confirmation of Lycopene's Benefits Remains Elusive
March 06, 2014 – Deborah Tolmach Sugerman
Taking Immune Action Against Lung Cancer
March 08, 2014 – Heather L. Van Epps, PhD
Pipeline
March 08, 2014 – Lindsay Ray
Preserving Security with Electronic Health Portals
March 06, 2014 – Charlotte Huff
The "To Do" List to Pass On to Well-Meaning Friends
March 08, 2014 – Don Vaughan
Choosing Quality Care
March 08, 2014 – Len Lichtenfeld, MD
Mobile App Delivers Helpful Tips to Minimize Side Effects
March 08, 2014
Legislations Could Benefit Family Caregivers
March 08, 2014 – Lena Huang
Exercise Improves Joint Pain Associated with Aromatase Inhibitors
March 08, 2014 – Jon Garinn
Moving Beyond Cancer to Wellness
March 08, 2014
Breast Cancer Prevention Study Focuses on Anti-Hormone Therapy
March 08, 2014 – Jon Garinn
Correspondent Amy Robach Receives Treatment
February 28, 2014 – Lindsay Ray
No Link Between Fertility Treatment and Overall Risk of Childhood Cancer
March 07, 2014 – Katherine Lagomarsino
Alzheimer's Disease and Cancer
March 06, 2014 – Sonya Collins
Research Updates
February 28, 2014 – Elizabeth Whittington
Genetics Leading the Way in Lung Cancer Treatment
March 05, 2014 – Debu Tripathy, MD
Letters From Readers
March 08, 2014
For Many, Caregiving Leads to Advocacy
March 07, 2014 – Jane Hill
Calming Chronic Inflammation
March 07, 2014 – Erik Ness
Making the Most Out of Your Patient Portal
March 07, 2014 – Charlotte Huff
Disclosing a Cancer Diagnosis Takes Time and Tact
March 05, 2014 – Don Vaughan
National Guidelines Aim to Make Life Better After Cancer
March 07, 2014 – Katy Human
Research Reveals New Frontiers in Lung Cancer
March 06, 2014 – Heather L. Van Epps, PhD
Biomarkers Help Patients Make Better Medical Decisions
March 06, 2014 – Laura Beil
Taking It Personally
March 07, 2014 – Laura Beil
Advocacy in Action
March 08, 2014 – Jane Hill
Can a Pill Prevent Cancer?
March 08, 2014 – Erik Ness
New Requirements for Patients and Survivors Needs
March 08, 2014 – Katy Human
How Survivors Can Take Action
March 08, 2014
Promises to Keep
March 06, 2014 – Tracy Stewart
Aiming to Improve Quality of Cancer Care
March 06, 2014 – Shelley Fuld Nasso
Confirmation of Lycopene's Benefits Remains Elusive
March 06, 2014 – Deborah Tolmach Sugerman
Taking Immune Action Against Lung Cancer
March 08, 2014 – Heather L. Van Epps, PhD
Pipeline
March 08, 2014 – Lindsay Ray
Preserving Security with Electronic Health Portals
March 06, 2014 – Charlotte Huff
The "To Do" List to Pass On to Well-Meaning Friends
March 08, 2014 – Don Vaughan
Choosing Quality Care
March 08, 2014 – Len Lichtenfeld, MD
Mobile App Delivers Helpful Tips to Minimize Side Effects
March 08, 2014
Legislations Could Benefit Family Caregivers
March 08, 2014 – Lena Huang
Currently Viewing
Exercise Improves Joint Pain Associated with Aromatase Inhibitors
March 08, 2014 – Jon Garinn
Breast Cancer Prevention Study Focuses on Anti-Hormone Therapy
March 08, 2014 – Jon Garinn
Correspondent Amy Robach Receives Treatment
February 28, 2014 – Lindsay Ray
No Link Between Fertility Treatment and Overall Risk of Childhood Cancer
March 07, 2014 – Katherine Lagomarsino
Alzheimer's Disease and Cancer
March 06, 2014 – Sonya Collins
Research Updates
February 28, 2014 – Elizabeth Whittington
Genetics Leading the Way in Lung Cancer Treatment
March 05, 2014 – Debu Tripathy, MD
Letters From Readers
March 08, 2014
For Many, Caregiving Leads to Advocacy
March 07, 2014 – Jane Hill
Calming Chronic Inflammation
March 07, 2014 – Erik Ness
Making the Most Out of Your Patient Portal
March 07, 2014 – Charlotte Huff
Disclosing a Cancer Diagnosis Takes Time and Tact
March 05, 2014 – Don Vaughan
National Guidelines Aim to Make Life Better After Cancer
March 07, 2014 – Katy Human
Research Reveals New Frontiers in Lung Cancer
March 06, 2014 – Heather L. Van Epps, PhD
Biomarkers Help Patients Make Better Medical Decisions
March 06, 2014 – Laura Beil
The Priority List: A Teacher's Final Quest to Discover Life's Greatest Lessons
March 08, 2014
What to Do When Radiation Causes Skin Damage
March 07, 2014 – Lacey Meyer

Exercise Improves Joint Pain Associated with Aromatase Inhibitors

BY Jon Garinn
PUBLISHED March 08, 2014

Postmenopausal women whose breast cancer is fueled by hormones (estrogen receptor-positive breast cancer) are typically prescribed aromatase inhibitors (AIs), a class of drugs that includes anastrozole, letrozole and exemestane, for five years after surgery or primary treatment.

AIs stop the production of estrogen by blocking the enzyme aromatase, which converts the hormone androgen into estrogen. But AIs can sometimes cause harmful side effects, such as bone loss and rarely heart problems. The most common side effect, experienced by about half of women taking an AI, is arthralgia, a joint pain so persistent that it is reported to be the main reason women stop taking the drug.

At the 2013 San Antonio Breast Cancer Symposium, Melinda L. Irwin, co-leader of the Cancer Prevention and Control Research Program at the Yale Cancer Center, presented data from a randomized trial that investigated the impact of a yearlong exercise program on women who were taking AIs and experiencing joint pain.

The HOPE (Hormone and Physical Exercise) study examined 121 women who were physically inactive but able to exercise and who had been taking an AI for at least six months.

The participants, all of whom reported experiencing at least mild joint pain, were randomized to receive standard care (which included written information on the importance of exercise) or to participate in an exercise program that included twice-weekly supervised resistance and strength training sessions and at least 150 minutes per week of moderate-intensity aerobic exercise. Participants in the exercise group received free personal training and gym memberships.

After 12 months, the participants in the exercise group experienced a 20 to 30 percent decrease in joint pain, in addition to other benefits, such as weight loss and an increase in cardio-respiratory fitness. Participants receiving standard care reported a slight increase in pain.

Be the first to discuss this article on CURE's forum. >>
Talk about this article with other patients, caregivers, and advocates in the General Discussions CURE discussion group.

Related Articles

1
×

Sign In

Not a member? Sign up now!
×

Sign Up

Are you a member? Please Log In