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March 07, 2014 – Laura Beil
Advocacy in Action
March 08, 2014 – Jane Hill
Can a Pill Prevent Cancer?
March 08, 2014 – Erik Ness
New Requirements for Patients and Survivors Needs
March 08, 2014 – Katy Human
How Survivors Can Take Action
March 08, 2014
Promises to Keep
March 06, 2014 – Tracy Stewart
Aiming to Improve Quality of Cancer Care
March 06, 2014 – Shelley Fuld Nasso
Confirmation of Lycopene's Benefits Remains Elusive
March 06, 2014 – Deborah Tolmach Sugerman
Taking Immune Action Against Lung Cancer
March 08, 2014 – Heather L. Van Epps, PhD
Pipeline
March 08, 2014 – Lindsay Ray
Preserving Security with Electronic Health Portals
March 06, 2014 – Charlotte Huff
The "To Do" List to Pass On to Well-Meaning Friends
March 08, 2014 – Don Vaughan
Choosing Quality Care
March 08, 2014 – Len Lichtenfeld, MD
Mobile App Delivers Helpful Tips to Minimize Side Effects
March 08, 2014
Legislations Could Benefit Family Caregivers
March 08, 2014 – Lena Huang
Exercise Improves Joint Pain Associated with Aromatase Inhibitors
March 08, 2014 – Jon Garinn
Moving Beyond Cancer to Wellness
March 08, 2014
Breast Cancer Prevention Study Focuses on Anti-Hormone Therapy
March 08, 2014 – Jon Garinn
Correspondent Amy Robach Receives Treatment
February 28, 2014 – Lindsay Ray
No Link Between Fertility Treatment and Overall Risk of Childhood Cancer
March 07, 2014 – Katherine Lagomarsino
Alzheimer's Disease and Cancer
March 06, 2014 – Sonya Collins
Research Updates
February 28, 2014 – Elizabeth Whittington
Genetics Leading the Way in Lung Cancer Treatment
March 05, 2014 – Debu Tripathy, MD
Letters From Readers
March 08, 2014
For Many, Caregiving Leads to Advocacy
March 07, 2014 – Jane Hill
Calming Chronic Inflammation
March 07, 2014 – Erik Ness
Making the Most Out of Your Patient Portal
March 07, 2014 – Charlotte Huff
Disclosing a Cancer Diagnosis Takes Time and Tact
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National Guidelines Aim to Make Life Better After Cancer
March 07, 2014 – Katy Human
Research Reveals New Frontiers in Lung Cancer
March 06, 2014 – Heather L. Van Epps, PhD
Biomarkers Help Patients Make Better Medical Decisions
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Advocacy in Action
March 08, 2014 – Jane Hill
Can a Pill Prevent Cancer?
March 08, 2014 – Erik Ness
New Requirements for Patients and Survivors Needs
March 08, 2014 – Katy Human
How Survivors Can Take Action
March 08, 2014
Promises to Keep
March 06, 2014 – Tracy Stewart
Aiming to Improve Quality of Cancer Care
March 06, 2014 – Shelley Fuld Nasso
Confirmation of Lycopene's Benefits Remains Elusive
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Taking Immune Action Against Lung Cancer
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The "To Do" List to Pass On to Well-Meaning Friends
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Mobile App Delivers Helpful Tips to Minimize Side Effects
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Exercise Improves Joint Pain Associated with Aromatase Inhibitors
March 08, 2014 – Jon Garinn
Moving Beyond Cancer to Wellness
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Breast Cancer Prevention Study Focuses on Anti-Hormone Therapy
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Correspondent Amy Robach Receives Treatment
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No Link Between Fertility Treatment and Overall Risk of Childhood Cancer
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Research Updates
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March 05, 2014 – Don Vaughan
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Genetics Leading the Way in Lung Cancer Treatment

CURE editor-in-chief Debu Tripathy introduces readers to the CURE Spring 2014 issue.

BY Debu Tripathy, MD
PUBLISHED March 05, 2014

Lung cancer is one of the most common and virulent cancers, and, despite improvements, it is still the leading cause of cancer death. This is because it is often detected at later stages, when surgery is less successful and medical therapies are less effective. As you will read in this issue, both of these factors are changing, providing an opportunity to improve outcomes.

Early detection through computed tomography scans for current or previous smokers is now a reality and has finally received the gold seal of approval from the U.S. Preventive Services Task Force. But screening is not perfect and sometimes results in unnecessary biopsies and surgeries. And it’s obvious that prevention is the best approach to eradicating lung cancer, because at least 80 percent of cases are due to smoking. We must not let up our guard to continue the trend in eliminating smoking as a societal priority.

The more robust, recent advances have been due to our understanding of genetic mutations that can be targeted with specific drugs.

The other area of rapid change has been in medical treatments. While chemotherapy can improve the cure rate for early-stage lung cancer, it is not curative for advanced metastatic lung cancer, and survival rates in this situation have remained essentially unchanged until recently. We have a long way to go, but the barrier was initially cracked with targeted therapies, such as the drug Avastin (bevacizumab), which added a median of about two months’ survival time (and longer for some patients).

The more robust, recent advances have been due to our understanding of genetic mutations that can be targeted with specific drugs. Even for those patients with no specific “sensitizing” mutations, newer immune therapies—after decades of negative studies—are now yielding promising results as we learn more about the basic science of immune regulation. The new generation of biomarker-driven trials will ultimately lay the groundwork for personalized medicine. If we couple earlier detection with genetically tailored treatment to prevent (as opposed to manage) metastases, the survival statistics could change radically—a very welcome change, indeed.

Debu Tripathy, MD
Editor-in-Chief
Professor of Medicine, University of Southern California
Co-Leader, Women’s Cancer Program at the USC/Norris Comprehensive Cancer Center

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