One Million Strong
January 25, 2018 – Kristie L. Kahl
A Cut Above Open Surgery
March 17, 2018 – MEERI KIM, PH.D.
High Expectations for Immunotherapy in GI Cancers
March 18, 2018 – ARLENE WEINTRAUB
Cabometyx Improves Survival in Patients With Advanced Hepatocellular Carcinoma
March 21, 2018 – Silas Inman
Immunotherapy After Targeted Drug Shows Promise in Advanced Liver Cancer
March 22, 2018 – Wayne Kuznar
On the Double: Improving Survival Rates in Pancreatic Cancer
March 25, 2018 – JANE DE LARTIGUE, PH.D.
Currently Viewing
Chemo Regimen Helps Control Locally Advanced Pancreatic Cancer
March 23, 2018 – Silas Inman
Paying it Forward
March 30, 2018 – Beth Fand Incollingo
All Over the Map When It Comes to Survivorship
April 04, 2018 – BETH FAND INCOLLINGO and STACY VERNER
A Major Turnaround for Liver Cancer
April 04, 2018 – GINA COLUMBUS and BETH FAND INCOLLINGO
A New Year Brings Treatment Options and Hope for Patients With Gastrointestinal Cancers
April 05, 2018 – MIKE HENNESSY, SR.
Every Patient Who Has a GI Cancer Should Be Tested for MSI-High Status
April 05, 2018 – DEBU TRIPATHY, M.D.
Looking Within: Exploring Genomic Testing for GI Cancers
April 05, 2018 – Danielle Bucco

Chemo Regimen Helps Control Locally Advanced Pancreatic Cancer

“Disease control is key in our patients with locally advanced disease, as it may lead to opportunities for additional treatment interventions, including radiotherapy, or even, in some favorable cases, surgical resection,” said lead study author Pascal Hammel, M.D., Ph.D.
BY Silas Inman
PUBLISHED March 23, 2018
INDUCTION TREATMENT WITH TWO chemotherapies — Abraxane (nabpaclitaxel) and Gemzar (gemcitabine) — demonstrated a time to treatment failure of 8.8 months for patients with newly diagnosed, locally advanced pancreatic cancer, according to updated findings from the phase 2 LAPACT trial.

In the single-arm, international trial, the Abraxane regimen elicited an objective response rate of 32 percent. The overall disease control rate was 77.6 percent. The median progression-free survival was 10.8 months with the combination, and the 12-month overall survival rate was 72 percent.

“Disease control is key in our patients with locally advanced disease, as it may lead to opportunities for additional treatment interventions, including radiotherapy, or even, in some favorable cases, surgical resection,” said lead study author Pascal Hammel, M.D., Ph.D., a gastroenterologist/ oncologist at Hôpital Beaujon in Clichy, France. “The results from this study are encouraging, as it shows that induction therapy has the potential to help us achieve disease control in these locally advanced patients.”

The study enrolled 106 patients with locally advanced pancreatic cancer. None had received prior therapy for pancreatic cancer and all had disease that was classified as inoperable.

All six cycles of induction therapy were completed by 57.5 percent of participants. Overall, 15 percent of patients went on to surgical resection following treatment with the regimen. Those who completed induction but did not receive surgery went on to chemoradiation (16 percent) or continued Abraxane and Gemzar (11 percent).

The most frequently observed serious treatment-emergent side effects were reduced white blood cell count (42 percent) and anemia (11 percent), and, in 10 percent of patients or less, fatigue, low blood platelet count, nerve dysfunction causing numbness or weakness, diarrhea and low white blood cell count with fever.

The combination of Abraxane and Gemzar was approved for patients with metastatic pancreatic cancer in 2013. Since then, “the regimen has become a standard of care in firstline metastatic pancreatic cancer,” Nadim Ahmed, president of hematology and oncology for the regimen’s developer, Celgene, said in a statement. “The findings from LAPACT offer insight into the potential of Abraxane-based treatment for locally advanced pancreatic cancer patients, and it’s encouraging to see a nearly ninemonth time-to-treatment failure in these patients treated with an Abraxane regimen.”
Be the first to discuss this article on CURE's forum. >>
Talk about this article with other patients, caregivers, and advocates in the Pancreatic Cancer CURE discussion group.

Related Articles

1
×

Sign In

Not a member? Sign up now!
×

Sign Up

Are you a member? Please Log In