Expert Urges Patients to Speak Up About Treatment Side Effects

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Jeffrey Weber, M.D., Ph.D., Deputy Director of the Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center, discusses how important it is that patients speak up when they experience side effects from their cancer treatments.

Jeffrey Weber, M.D., Ph.D., Deputy Director of the Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center, discusses how important it is that patients speak up when they experience side effects from their cancer treatments. This is particularly important as checkpoint inhibitors such as Opdivo (nivolumab) and Yervoy (ipilimumab) continue to move into the treatment realm for melanoma.

Gastrointestinal toxicity is one of the most dangerous side effects that patients receiving Opdivo plus Yervoy can experience, but if they are taken care of sooner, rather than later, severe and potentially life-threatening events can be avoided. In his experience as an oncologist treating patients with melanoma, Weber said that many of the major problems regarding toxicities happen when patients wait days to tell their health care team about an issue that they are having.

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For patients with cancer, the ongoing chemotherapy shortage may cause some anxiety as they wonder how they will receive their drugs. However, measuring drugs “down to the minutiae of the milligrams” helped patients receive the drugs they needed, said Alison Tray. Tray is an advanced oncology certified nurse practitioner and current vice president of ambulatory operations at Rutgers Cancer Institute in New Jersey.  If patients are concerned about getting their cancer drugs, Tray noted that having “an open conversation” between patients and providers is key.  “As a provider and a nurse myself, having that conversation, that reassurance and sharing the information is a two-way conversation,” she said. “So just knowing that we're taking care of you, we're going to make sure that you receive the care that you need is the key takeaway.” In June 2023, many patients were unable to receive certain chemotherapy drugs, such as carboplatin and cisplatin because of an ongoing shortage. By October 2023, experts saw an improvement, although the “ongoing crisis” remained.  READ MORE: Patients With Lung Cancer Face Unmet Needs During Drug Shortages “We’re really proud of the work that we could do and achieve that through a critical drug shortage,” Tray said. “None of our patients missed a dose of chemotherapy and we were able to provide that for them.” Tray sat down with CURE® during the 49th Annual Oncology Nursing Society Annual Congress to discuss the ongoing chemo shortage and how patients and care teams approached these challenges. Transcript: Particularly at Hartford HealthCare, when we established this infrastructure, our goal was to make sure that every patient would get the treatment that they need and require, utilizing the data that we have from ASCO guidelines to ensure that we're getting the optimal high-quality standard of care in a timely fashion that we didn't have to delay therapies. So, we were able to do that by going down to the minutiae of the milligrams on hand, particularly when we had a lot of critical drug shortages. So it was really creating that process to really ensure that every patient would get the treatment that they needed. For more news on cancer updates, research and education, don’t forget to subscribe to CURE®’s newsletters here.
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