A Chemotherapy No-Brainer

Article

It appears that we survivors have, at long last, been taken seriously about our reports of problems with mental functioning as a result of chemotherapy.

It appears that we survivors have, at long last, been taken seriously about our reports of problems with mental functioning as a result of chemotherapy. A recent article in Medical News Today leads with the title, Potential New Treatment Found for “Chemo Brain.”

Is it possible that those of us who have reported the mind slips of forgetting names for everyday items (a recent survivor shared with me that she could not remember “the name for the cloth that covers a table”) confusion, poor attention, difficulty focusing, etc. now have vindication? Could it be true that after being told that it is all in our heads, science has now found that it's in our brains? At first blush the answer seems to be “yes.” Unfortunately, the article, while promising in outline, is skimpy on the details.

My first thought in reading “new treatment” was, “Was there ever an old treatment?” If there was, I don’t remember it. But, then again, maybe that’s my chemo brain acting up. The other subtle point is that even the condition itself is placed in quotation marks. This is not standard treatment for a diagnosable ailment. We are not told, when that awful day arrived, that we had “cancer.” The quotations marks are explained in the sentence, "[Chemo brain is] something doctors learned about because patients were complaining." This is akin to the sentence, “My therapist says I suffer from being ‘too nice.’”

The article does take on a more scholarly tone as it describes the “damage” caused by chemotherapy medications to the brain cells protective layer and the decrease in the “feel good” hormones, dopamine and serotonin. It even gets a little creepy when it talks about the increase in hydrogen peroxide in the brain as a result of certain chemo drugs. Admittedly, I don’t know what hydrogen peroxide is doing in the brain in the first place, but its increase just sounds bad. As I read on, eagerly awaiting the good news, I was stunned to read, “These are the first studies to our knowledge that look at what happens to neurotransmitter release events as a result of these chemotherapeutic agents. It hopefully will open up some options for treatments down the road.” I found myself trying to scroll down the page looking for the promised treatment. Surely, no one, not suffering from chemo brain, would be as thoughtless as to promise relief from this frustrating side effect and end with “treatments down the road.” Really! What treatments and what road?

So, while we are, apparently, still waiting for a true treatment for chemobrain, we can take heart in the knowledge that our voices have been heard and something is being done. And, while we as survivors are once again being asked to show great patience while others decide if it’s “important for researchers” to develop therapies, let’s keep complaining. Let’s keep sharing our stories about what it’s like to live with a brain that’s been through the cancer challenge and perhaps the next article on the subject will begin with the title, A Chemo-No-Brainer: The Real Effects of Chemotherapy and A Proven Treatment.

Related Videos
For patients with cancer, the ongoing chemotherapy shortage may cause some anxiety as they wonder how they will receive their drugs. However, measuring drugs “down to the minutiae of the milligrams” helped patients receive the drugs they needed, said Alison Tray. Tray is an advanced oncology certified nurse practitioner and current vice president of ambulatory operations at Rutgers Cancer Institute in New Jersey.  If patients are concerned about getting their cancer drugs, Tray noted that having “an open conversation” between patients and providers is key.  “As a provider and a nurse myself, having that conversation, that reassurance and sharing the information is a two-way conversation,” she said. “So just knowing that we're taking care of you, we're going to make sure that you receive the care that you need is the key takeaway.” In June 2023, many patients were unable to receive certain chemotherapy drugs, such as carboplatin and cisplatin because of an ongoing shortage. By October 2023, experts saw an improvement, although the “ongoing crisis” remained.  READ MORE: Patients With Lung Cancer Face Unmet Needs During Drug Shortages “We’re really proud of the work that we could do and achieve that through a critical drug shortage,” Tray said. “None of our patients missed a dose of chemotherapy and we were able to provide that for them.” Tray sat down with CURE® during the 49th Annual Oncology Nursing Society Annual Congress to discuss the ongoing chemo shortage and how patients and care teams approached these challenges. Transcript: Particularly at Hartford HealthCare, when we established this infrastructure, our goal was to make sure that every patient would get the treatment that they need and require, utilizing the data that we have from ASCO guidelines to ensure that we're getting the optimal high-quality standard of care in a timely fashion that we didn't have to delay therapies. So, we were able to do that by going down to the minutiae of the milligrams on hand, particularly when we had a lot of critical drug shortages. So it was really creating that process to really ensure that every patient would get the treatment that they needed. For more news on cancer updates, research and education, don’t forget to subscribe to CURE®’s newsletters here.
Yuliya P.L Linhares, MD, an expert on CLL
Yuliya P.L Linhares, MD, and Josie Montegaard, MSN, AGPCNP-BC, experts on CLL
Image of a man with a beard.
Image of a man with gray facial hair and a navy blue suit with a light orange tie.
Image of a woman with black hair.
Related Content