Before signs or symptoms begin, leukemias can be discovered through a routine blood test. If signs or symptoms warrant further evaluation, a patient will undergo a physical examination, blood tests or a bone marrow test

Signs and symptoms can include fever or chills; persistent fatigue or weakness; frequent or severe infections; losing weight without trying; swollen lymph nodes or an enlarged liver or spleen; easy bleeding or bruising; recurrent nosebleeds; tiny red spots in the skin, excessive sweating, especially at night; or bone pain or tenderness.