Liver cancer starts in the liver, the largest internal organ, when cells mutate in their DNA.

Signs and symptoms of liver cancer may include losing weight without trying, loss of appetite, upper abdominal pain, nausea and vomiting, general weakness and fatigue, abdominal swelling, yellow discoloration of your skin and the whites of your eyes, or white, chalky stools.

Risk factors for the disease include chronic infection with HBV or HCV, cirrhosis, inherited liver diseases (hemochromatosis or Wilson's disease), diabetes, nonalcoholic fatty liver disease, exposure to aflatoxins and excessive alcohol consumption.