Clinical Trial Corner

Can a Blood Test Detect Lung Cancer in High-Risk Adults?

January 19th 2022

A new study to evaluate the accuracy of a blood test for detecting lung cancer in high-risk adults has enrolled its first participant with plans to enroll thousands more.

Enrollment Begins for First-Line Maintenance Vaccine for Metastatic CRC

January 13th 2022

Enrollment has begun for a trial evaluating a vaccine as first-line maintenance treatment for metastatic, microsatellite-stable colorectal cancer.

Trial Underway for Potential First Treatment Option of Newly Diagnosed NPM1-Mutant AML

January 12th 2022

A phase 3 trial has begun to examine entospletinib, a selective inhibitor, as a treatment for patients with newly diagnosed NPM1-mutated acute myeloid leukemia.

Trial Launched to Assess Safety and Efficacy of Novel Drug in Rare Type of Head and Neck Cancer

January 10th 2022

A phase 2 trial was recently launched to examine the safety and efficacy of oral inhibitor VK-2019 in patients with advanced Epstein-Barr Virus-positive nasopharyngeal carcinoma, a rare type of head and neck cancer, and lymphoma.

Trial Underway to Assess Efficacy of Novel Radiopharmaceutical Drug in Neuroendocrine Tumors

January 5th 2022

The phase 3 COMPOSE trial will look at the efficacy of using 177lu-edotreotide — a novel radiopharmaceutical that is designed to limit radiation exposure to normal tissue — in patients with later stage neuroendocrine tumors.

5 Cancer Clinical Trials You May Have Missed

December 18th 2021

There are many cancer clinical trials that patients can enroll in across the United States. Here is a snapshot of some of the more recent ones.

Oncolytic Virus Clinical Trial Opens for Patients With Advanced Breast Cancer

December 17th 2021

City of Hope has opened its first-in-human clinical trial for an investigational therapy in patients with advanced breast cancer.

Novel Therapy Being Assessed for the Treatment of RAF-Altered Solid Tumors

December 3rd 2021

Investigators plan to analyze the safety and efficacy of a novel cancer therapy for the treatment of patients with RAF-altered solid tumors.

First Patient Randomized in Phase 2 Trial for NSCLC Treatment Combination

December 1st 2021

The first patient was randomized in the phase 2 trial examining Tedopi and Opdivo for non-small cell lung cancer.

Expansion of IOA-244 Trial Fully Enrolled for Uveal Melanoma

November 26th 2021

Part B of the DIONE-01 study will look at whether IOA-244 increases anti-tumor responses in expansion groups of patients.

Phase 2 Trial Initiated for Second Line Treatment of AML and MDS

November 18th 2021

A phase 2 trial of aspacytarabine (BST-236) was initiated in patients with AML and MDS.

CAR-T Cell Therapy Trial Currently Enrolling Patients With CLL and SLL

November 16th 2021

The TRANSCEND CLL 004 trial is currently enrolling patients to determine the efficacy of a CAR-T cell therapy.

First Patient Receives Novel Immunotherapy in Bladder Cancer Sub-Study

November 13th 2021

The first patient with bladder cancer was dosed in a phase 1/2 trial examining responses to an investigational immunotherapy.

Enrollment Begins in Devimistat Trial for Patients With Relapsed Clear Cell Sarcoma

November 12th 2021

The first patient has been enrolled in the APOLLO 613 Phase 1/2 clinical trial for CPI-613.

Study Initiated for Bispecific Antibody in Patients With T-cell Lymphoma

November 10th 2021

A phase 1 trial of ONO-4685 was initiated for the evaluation of the antibody in patients with relapsed or refractory t-cell lymphoma.

BOLD-100 Trial Receives FDA Clearance for Treatment of Advanced GI Cancers

November 4th 2021

The Food and Drug Administration gave clearance to Bold Therapeutics for a phase 1b/2a trial examining treatments for advanced GI cancers.

Patients Dosed in Trial of Topical Gel for Dose-Limiting Acneiform Lesions in Patients With Colorectal Cancer

November 1st 2021

The first patients were dosed in a phase 2 trial for a topical gel to treat lesions in patients with colorectal cancer receiving EGFR inhibitor therapy.

Clinical Trial Launched for Preventive Breast Cancer Vaccine

October 28th 2021

Cleveland Clinic’s Lerner Research Institute has initiated a new study to examine a vaccine to prevent triple-negative breast cancer.

New Trial Initiated for Fosciclopirox in Patients With Bladder Cancer

October 26th 2021

A phase 1b trial started to study the effects of fosciclopirox in patients with newly diagnosed and recurrent bladder cancer.

Phase 1 Trial Begins for New Treatment Delivery Strategy in Pancreatic Cancer

October 22nd 2021

Celsion GmbH has initiated a phase 1 trial to analyze ThermoDox with focused ultrasound for patients with pancreatic cancer.

First Patient With NTRK Fusion-Positive Tumor Treated in Phase 2 Trial of Taletrectinib

October 19th 2021

A company focused on treating underserved patients announced that the first patient with an NTRK fusion was dosed in a phase 2 trial of taletrectinib this summer.

First Patient With Squamous Cell Carcinoma Dosed in Phase 2 Trial for Vilobelimab

October 17th 2021

The first patient was enrolled and dosed in InflaRx’s phase 2 trial of vilobelimab for the treatment of cutaneous squamous cell carcinoma.

Trial Initiated to Assess Efficacy of Cosela in Bladder Cancer

October 14th 2021

The PRESERVE 3 trial began this summer to determine efficacy of using Cosela with platinum-based chemotherapy in patients with metastatic bladder cancer.

Trial for Novel Advanced Prostate Cancer Drug Enrolls First Patient

October 11th 2021

The first patient was enrolled in a phase 2 clinical trial for the treatment of hormone-sensitive advanced prostate cancer.

Trial Initiated for Chemoprotective Agent to Treat Non-Small Cell Lung Cancer

October 10th 2021

Aileron Therapeutics, Inc. announced the initiation of a clinical trial for ALRN-6924, a treatment for patients with non-small cell lung cancer.

Milademetan Introduced for Patients With De-Differentiated Liposarcoma in Clinical Trial

October 5th 2021

A phase 3 clinical trial has begun to evaluate the efficacy and safety of milademetan in patients with de-differentiated liposarcoma.

First Patient With Lung Cancer Treated in Phase 2b Tomivosertib Trial

September 24th 2021

The first patient was treated in the phase 2b KICKSTART trial testing the safety and efficacy of tomivosertib in combination with Keytruda.

Enrollment Complete in Phase 3 MOMENTUM Myelofibrosis Trial

September 21st 2021

Sierra Oncology completed enrollment for its phase 3 MOMENTUM clinical trial for the treatment of patients with myelofibrosis.

Phase 2 BCG-Unresponsive Bladder Cancer Study Gets the OK to Start Enrollment

September 1st 2021

Patients with Bacillus Calmette Guérin-unresponsive carcinoma in-situ will be treated at the University of Chicago in a Theralase study.

First Patient Dosed in Expansion of Phase 1 Clinical Trial for Squamous Cell Carcinoma

August 31st 2021

The first patient with HPV-positive head and neck squamous cell carcinoma received their dose of in the CUE-101 phase 1b trial.

Investigational Cancer Treatment Being Evaluated in B-Cell Malignancies

August 23rd 2021

Researchers are evaluating the safety and efficacy of zandelisib, an investigational cancer therapy, for the treatment of patients with marginal zone lymphoma and follicular lymphoma who have received at least two prior therapies.

Patient Recruitment Has Begun for Trial Assessing Cosela in Metastatic Bladder Cancer

August 20th 2021

Preliminary results of the phase 2 trial assessing the safety and efficacy of Cosela with gemcitabine/platinum-based chemotherapy and Bavencio maintenance therapy for metastatic bladder cancer are expected to be released in the second half of 2022.

CURE’s Clinical Trial Corner: June 2021

June 24th 2021

As the cancer treatment landscape continues to expand, patients and their caregivers should be aware of the various clinical trials currently being conducted — including studies they can possibly join.

CURE’s Clinical Trial Corner: May 2021

May 27th 2021

As the cancer treatment landscape continues to expand, patients and their caregivers should be aware of the various clinical trials currently being conducted — including studies they can possibly join.

CURE’s Clinical Trial Corner: April 2021

April 29th 2021

Here is a list of some recent trials that launched within the cancer space in April.

CURE’s Clinical Trial Corner: March 2021

March 25th 2021

Here is a list of some recent trials that launched within the cancer space in March.

CURE’s Clinical Trial Corner: February 2021

February 25th 2021

Here is a list of some recent trials that launched within the cancer space in February.

CURE’s Clinical Trial Corner: January 2021

January 28th 2021

Here is a list of some recent trials that launched within the cancer space in January.