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“This study comes from a very honest place. Because I want all patients out there with lung cancer to feel empowered to ask their doctor because they don't have to suffer in silence,” said Dr. Narjust Duma.

International Survey to Assess How Lung Cancer Treatment Affects Women’s Sexual Health

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Hope for Stomach Cancer helps provide awareness for patients with stomach cancer and their caregivers.


Stomach Cancer Awareness

Patient navigators are the vaunted “healthcare emissaries” for patients with breast cancer and can help navigate their journey a great deal. In this conversation from the Susan G. Komen Greater New York City “Empowering and Mobilizing Our Patient Navigation Workforce” virtual conference experts highlight the results of a survey of patient navigators.
 

Knowing Your Community of Patient Navigators

On the Today Show, Scott Hamilton share's his cancer story and also gives a look at his book "Frtizy Finda A Hat",  a children's book to help parents talk about cancer with their kids. 

Scott Hamilton Shares His Story

After the devastating explosion in Beirut, dozens of children with cancer are now left without access to treatment as the region tries to find a way forward.

"It's hard to know that we have a deadly but treatable disease, and we cannot do anything for these kids because everything is destroyed," Peter Noun, the head of St. George's pediatric hematology and oncology department in Beirut, Lebanon, said in an 

. St. George’s Hospital, one of the city’s biggest hospitals, was one of two hospitals damaged in the explosion.

For the children being sent away from cancer centers, operating hospitals in the area are currently overwhelmed from treating the more than 5,000 people injured from the blast, but also have the threat of the novel coronavirus that is rising in Lebanon. Critical cancer patients have been sent to hospitals outside of the country, but Noun is worried more won’t have treatment if field hospitals aren’t ready soon enough.

At the age of 13, Caitlyn Mortus was diagnosed with cancer and had to receive treatment at MD Anderson’s Children’s Cancer Hospital. Ten years later, Mortus is working at the same hospital as a pediatric oncology nurse.

During her time at MD Anderson as a patient undergoing chemotherapy, Mortus found inspiration and encouragement from the nurses that helped her through her treatment to pursue her dreams of joining their ranks, and now Mortus is working with some of the practitioners from her original care team.

Along with her efforts as a pediatric oncology nurse, Mortus is also using her experience to help address everyday problems kids with cancer face, like isolation from their friends and family. Through her non-profit, Keep Kids Connected, Mortus looks to provide every kid going through cancer treatment with a tablet or computer to help stay in touch with friends and family while isolated from treatment, an issue that Mortus went through herself and addressed by getting a working laptop and sharing it with other patients.

“I barely knew anything about cancer when I first came here,” she said in an 

, “but now it has shaped my life and made me into the person I am today.”

A 5-time cancer survivor rode 80 miles on a handcycle to help raise money and awareness for Chai Lifeline and the summer sleep away camp it sponsors for children with cancer, Camp Simcha.

JJ Eizik has been faced with cancer five times before his 30th birthday and has underwent 20 surgeries that included the loss of his left leg, where a cancerous tumor on his femur originated. While cancer has taken a major toll on his life, Eizik hasn’t lost his love for athletics, making the bike ride not just a charity event, but a way to keep pushing himself despite past hardships.

"My message always is and has been: When you think you're done, keep pushing," said Eizik, in an 

. "It's a mental attitude that you have to develop, that I had to develop. It carried me through a lot of hard times."

Eizik was among 40 other riders that helped raise over $6 million for the sleepaway camp.

Utilizing intestinal bacteria in cancer treatment could boost its effects four-fold, according to research from the University of Calgary.

According to the lead researchers, these intestinal microbiomes can help to “supercharge” the potency of targeted immunotherapies for patients with cancer when the bacteria essentially turns on a switch in the immune cell, activating T-cells to stop cancer by generating a tiny molecule called inosine.

“With cancers (normally) susceptible to immunotherapy 20% of the time, and it responds at 80%, that’s a major increase in efficacy,” explained Dr. Kathy McCoy of the Snyder Institute for Chronic Diseases at the U of C’s Cumming School of Medicine, in an 

. In this study, three types of bacteria were found to create the desired effect of making new specific T-cells to fight cancer.

“We actually found there was an increase in bacterium in the patients responding, but the studies were too small,” said McCoy. The researchers are seeking to expand their study to focus on lung cancer and melanoma over the next several years.

From the recent Beirut explosion compromising pediatric oncology hospitals, to researchers looking at how intestinal bacteria can supercharge targeted immunotherapies, here’s what’s happening in the cancer landscape this week. 

Friday Frontline: Beirut Explosion Costs Children’s Access to Cancer Treatment, Researchers Find Intestinal Bacteria ‘Supercharges’ Immunotherapy and More

Follicular Lymphoma Risk Factors, Diagnosis, Prognosis

Progression in R/R Follicular B-Cell Non-Hodgkin Lymphoma

Understanding Relapsed/Refractory Follicular Lymphoma

Emesis, the medical term for vomiting, is one of the most common side effects associated with cancer treatment, especially chemotherapy. But now the field has a host of antiemetic drugs to help prevent vomiting, a reality that wasn’t the case in the early days of medical oncology.

Dr. Richard J. Gralla was one of the leaders in the early medical oncology field looking at making supportive care an integral part of cancer care. Part of his work involved having patients with lung cancer take antiemetics to help prevent vomiting and avoid treatment discontinuation due to side effect fears.

® Gralla, director of oncology research for the North Bronx Healthcare Network, spoke about what the early days of research into cancer treatment-related emesis looked like and where supportive care stands now in the lung cancer space.

In those early days, when we were thinking what we should do, we needed to look at something a little different. Basically, over two or three days, or even less, I read the world's literature on clinical studies in emesis. It didn't take very long. However, these two pioneers, Boris and McCarthy, and several others had really worked out the physiology of emesis. And most of us really have not been well educated in reading their views and understanding the clinical problem.

We were able to look at some different areas, and then, because we've done work in phase one, said, hey, are we giving the right doses of these drugs? And then when we found ways that were working, the question came up: how are these working? And then it was through collaboration with some neuro pharmacologists, who were so bright and said, we think that these must be working in this pathway, not the original pathway, and the drugs that work in that pathway might be safer and more effective. And so that was kind of a fun way of putting that together. But then seeing the clinical aspect of it, as that nurse expressed to me, yeah, that’s true.

Then, one of my other interests has been in day hospitals, and doing (treatment) without overnight admissions in many, many aspects, and having proper antiemetics is kind of important for that. And then measuring, from a quality of life standpoint, do patients agree with us, and well let's hear the patient's voice. So, hearing those things together, has been very interesting and rewarding at the same time.

Dr. Ricahrd J Gralla discusses the history of the early medical oncology space and how things have changed when it comes to treating side effects related to chemotherapy. 

Pioneer in Supportive Care Research Discusses History of Emesis Management

In patients with diffuse large B-cell lymphoma (DLBCL), the most common form of non-Hodgkin lymphoma, low muscle mass (LMM) and low muscle density (LMD) could play a role when deciding what kind of treatment option to pursue, and could also impact a patient’s odds of survival, according to a recent study published in the journal 

In recent years, researchers have spent more time examining patients’ muscle mass and density in relation to how well they can tolerate treatment, the authors noted. However, many studies reporting on LMM and LMD often use different definitions for each term, and various factors relating to age or unfavorable disease characteristics also make it difficult to come to any concrete conclusions.

That’s why a team of researchers from the Netherlands set out to investigate how LMD, LMM and the combination of both relate to survival in patients with DLBCL, while also evaluating the prevalence of LMM and LMD in this patient population compared to a database of healthy kidney donors, which they used to create a standardized way to measure muscle.

In the single-center retrospective study, researchers used the Netherlands Cancer Registry to identify 164 patients with DLBCL that were diagnosed at a large regional hospital in the Netherlands between January 2006 and December 2015. Patients were excluded if they had a second active malignancy or a history of malignant lymphoma in the past. Information about the patient characteristics, height, weight, chemotherapeutic dosage and tumor response were all collected.

The primary endpoint of the study was overall survival (OS), defined as the date of diagnosis to the end of follow-up or death whichever came first. Secondary endpoints were progression-free survival (PFS), the complete remission (CR) rate and completion of planned treatment.

The median age of all patients was 64.5 years, with two-thirds of patients above age 60. One hundred and twenty-nine patients (79%) saw complete response after therapy, and the median duration of follow-up was 57 months. CT-based measurements of muscle mass were made on all 164 patients prior to chemo-immunotherapy, who were then given scores that were also adjusted for gender, age and body mass index derived from the healthy reference group.

Overall, the authors noted that the combination of LMM and LMD, which was found in 13% of patients, was an independent risk factor for shorter overall survival and progression-free survival.

When looking at what patients went on to complete treatment, they also found that patients with LMM and LMD frequently discontinued the standard treatment of chemotherapy combined with the monoclonal antibody Venclexta (rituximab). These patients were also less likely to achieve a complete response.

While the authors note that the lower CR-rate could be a result of treatment termination, they cited another study to offer further explanation. “In a study involving 187 DLBCL patients, CR-rate did not differ between patients with LMM and patients with normal muscle mass if it was possible to administer all planned treatment cycles,” they explained. “Therefore, it is possible that premature termination of treatment is the cause of the diminished CR-rate, highlighting the possibility that targeting LMM/LMD might result in a higher CR-rate, thereby improving survival.”

The authors also explained that OS and PFS in their study were highly comparable, leading them to believe that the cause of death in the patients they evaluated was mainly due to disease progression.

“Muscle measurement may help to guide optimization of chemotherapy dosage in order to reduce toxicity, while still maintaining oncological efficacy,” the authors concluded. However, in order to best benefit patients, standardization of muscle measurement is needed, and more study is needed to investigate the prognostic impact of LMM and LMD, and to determine if optimization of these factors during treatment could result in a higher CR-rate and prolonged survival.

In patients with diffuse large B-cell lymphoma, low muscle mass (LMM) and low muscle density (LMD) could play a role when deciding what kind of treatment option to pursue, and could also impact a patient’s odds of survival, according to a recent study. 

Muscle Mass and Density Could Factor Into Treatment Decisions and Survival for Some Patients with Lymphoma

While prostate cancer treatment can cause cardiovascular-related side effects, patients can take certain steps to mitigate those risks, according to Dr. Neal D. Shore, medical director of the Carolina Urologic Research Center.

’s sister publication, Shore recently discussed the role that general health-related interventions such as regular exercise and bloodwork play in keeping the risk of treatment-related cardiovascular toxicity low. Shore also touched on the idea that the choice of therapy could impact these risks in a positive way, based on the results of the recent HERO trial, which examined the use of the hormone-suppressing drug relugolix in this patient population.

Yeah, that's a very important question. The whole field of cardio oncology, across all the different oncology or cancer disease states, has gotten so much more traction. As we know, where we give testosterone suppression, we basically create what's described as this quasi-metabolic syndrome, where we see central adiposity (excessive body weight). We see, potentially, with LHR agonists — and it's in their label — a warning as it relates to arrythmia and potential QT prolongation (heart rhythm irregularities). We didn't see that with relugolix.

But what are the things that we can do? We can make sure that patients are following a better, heart-healthy diet, that they're regularly exercising (and) having their lipid panels and their cholesterol checked. If they have diabetes, they're under really tight glucose management, monitoring their hemoglobin A1C. And so, these are some factors, (including) avoidance of smoking (and) avoidance of a sedentary lifestyle; there are these classic, sort of ABCDE outlines that people can be thinking about.

I'm really happy and proud of our HERO trial, because this adds to a strategy to avoid cardiovascular toxicity, and yet at the same time achieve what we're trying to achieve, which is rapid T (testosterone) suppression and rapid PSA (prostate-specific antigen) corollary declines. We had really excellent results in our T levels that went below 20, even though less than 50 nanograms per deciliter is the pharmacologic endpoint for approval.

So, yes, we can be a lot more proactive in our cardio-oncology strategies, as well as in our prostate cancer therapeutic selections.

Prostate cancer treatments can cause side effects in a part of the body that might be unexpected— the heart. Here's how one expert believes patients can mitigate them. 

How Patients Can Mitigate the Heart-Related Side Effects of Prostate Cancer Treatment

In the winter of 2019, life was pretty perfect for me. I was 36 years old and happily practicing as a lawyer. But that’s when I suddenly started experiencing flu-like symptoms, back pain and night sweats. I went to the doctor not knowing exactly what was wrong. After a few tests, I was diagnosed with stage 4 non-Hodgkin lymphoma. My entire life stopped in an instant.

I started receiving chemotherapy and R-CHOP immediately, and with the support of my oncologist,

I started chemotherapy and R-CHOP immediately, and with the support of my oncologist Dr. Asghar H. Asghar from Memon Medical Institute Hospital and some other amazing supporters, I began my journey to beat cancer. I spent the next 60 days in and out of the hospital. In those 60 days, I learned what it really means to fight for your life. I experienced what it was like to receive chemotherapy. I lost more than $180,000 and all my dreams. I was on a feeding tube. And, I suffered many life-threatening infections. I remember there were days when I looked in the mirror and I did not recognize the frail, bald man looking back at me. In just over three months, I had gone from being carefree to being someone who required a caregiver.

Now thanks to Almighty Allah, I am so blessed to be able to say that I am in remission, and that life gets better and better every single day.

I know I was fortunate enough to have access to all the incredible medical treatments and support of my family members and Dr. Asghar, which all played a gigantic part in me beating cancer. Equally important was the support of my family and friends.

I also knew that I had to keep myself moving. Even though I was fighting for my life, I had to push just a little bit harder. My commitment to physical activity never stopped. Once I was in remission, I started going on walks to slowly rebuild my inner and outer strength. That was one of the best gifts I gave myself. It helped me reconnect with myself in a whole new way.

Beating cancer takes an unbelievable toll on you both mentally and physically. My body and mind were in constant survival mode. I experienced some depression, which is very normal for someone fighting cancer. Prayers to Allah really helped me reconnect with my body and spirit. It helped me process what had just happened and allowed me to work through all my feelings.

I understood early on in my cancer journey that it was going to be a physical and mental fight. How I thought about my fight with cancer was going to be just as important as my physical fight. I had a vision board that I kept in my room during my treatment to remind me of all the things I loved, and what I was fighting for. My vision represented hope and a beautiful future. It kept me motivated and focused on all the wonderful things that life still had to offer. I also learned in these troubled moments of life that laughter is the best medicine. Comedy became such an amazing outlet and relief for me while I was going through treatment. Prayers to Almighty Allah are so therapeutic and healing to my spirit, and it really helped me take my mind off all the heaviness around me.

I never gave up, even when I was scared. I believe anything is possible once you set your mind on it and we are willing to work hard to achieve it.

The cancer journey can show you what it really means to fight for your life. 

Cancer Taught Me What It Really Means to Fight for Your Life

After taking office as the Governor of Maryland, Larry Hogan began to experience some aches and pains that he chalked up to a whirlwind year of campaigning and travel. But when a handful of doctor’s visits led him to a series of CAT scans, he was devastated to hear the diagnosis: advanced, aggressive cancer.

, Hogan recently opened up about how he relied on the help of his family, both his personal and professional one, to take on treatment and eventually overcome the disease not once, but twice.

I had just been elected governor of Maryland and just was sworn in. I'd only been governor for five months and I was on our first trade mission to Korea, China and Japan. We had been really busy going through a year-long campaign, our first legislative session, had been working day and night. I had no idea I was really sick, but I started to have some aches and pains, and on this trip, I started to feel a little run down, but I thought it was I was okay. But I noticed a lump in my throat, and I said I better check this out.

And so I went to the doctor as soon as we got back, and the first primary care physician sent me to another doctor, who sent me to another doctor, and I ended up having three doctors after doing a bunch of CAT scans walk into the room together, which I said, this can't be a good sign when three doctors that you don't know walk into the room. And they said we have some bad news to share with you, governor: you have very advanced and aggressive cancer. We found about 50-some tumors from your neck to your groin, and we're going to have to set you up with a specialist oncologist right away.

I was, frankly, stunned that my first doctor said I didn't think it was anything to worry about. You know, it's probably just a benign cyst of some kind, fluid and my lymph node and my neck. And but then I heard this shocking news and it set off a whole series of things.

This was Father's Day weekend, the Friday of Father's Day weekend, and my very first thought was not really about being afraid of what was going to happen to me. But I think it's probably what so many other cancer patients go through, and my first thought was about my family, you know. How am I going to tell my wife? My three daughters were coming to visit for Father's Day weekend, I was going to break that news to them. And then my dad who was coming over for Father's Day weekend, and it doesn't matter how old you get, I was still his little boy. And he took it almost tougher than anybody, but it was a group hug, a little tears, and I thought everybody was going to be okay.

And then, I had to then break the news to my staff who worked so hard and just was getting started on our administration, and break it to the six million people of Maryland, who had just put their faith and trust in me to help run the state. I was trying to be as open and honest and transparent as I could possibly be with all the people of the state, and they kind of went through and shared the whole cancer battle with me.

After a cancer diagnosis, Maryland Governor Larry Hogan had to lean on family from both his personal and professional life to helping take on treatment and beat cancer twice. 

How Governor Larry Hogan Leaned on Family After a Cancer Diagnosis

Barbara Tako is a breast cancer survivor (2010), melanoma survivor (2014) and author of Cancer Survivorship Coping Tools—We'll Get You Through This. She is a cancer coping advocate, speaker and published writer for television, radio and other venues across the country. She lives, survives, and thrives in Minnesota with her husband, children and dog. See more at www.cancersurvivorshipcopingtools.com,or www.clutterclearingchoices.com.

Alfred, Lord Tennyson once wrote “'Tis better to have loved and lost than never to have loved at all” which, in my opinion, is mostly true. It may sometimes work better in theory than in life, but it is mutually important, helpful, and supportive to make friends with cancer.

I have said this hundreds of times: Do not do cancer alone. Yes, as with anything, there are positives and negatives. I completely believe the good things that come with bonding with friends with cancer outweigh the bad things. Cancer has a mental and emotional impact, as well as a physical one. And, we need each other.

Friends with cancer “get” what you're saying when you talk about your experiences, feelings, worries and more. While family and friends care about you, it can sometimes be tiring to have to explain and educate them about your cancer (that will be a whole different article discussion). Friends with cancer, even years down the road, understand your ongoing cancer anxieties without needing reminders or a refresher course. We get it.

When it comes to “cancer friends”, it helps to keep these thoughts in mind:

Remember that you will never quite be able to compare “apples” to “apples” when it comes to cancer decisions and situations. Even when you seem to share the “exact” same kind of cancer, you probably do not have the same exact genetics, age, or medical history!

Try not to play doctor. Your thoughts and opinions are just that, thoughts and opinions. Telling someone what they “should” or “need to” do is not kind or helpful, so be supportive.

Share educational resources and help each other formulate the best questions to bring to medical appointments.

Share emotional coping tools. Learn what helps each other. Distractions? Walks? Hobbies? If you have any in common, those are activities to enjoy together.

Above all, listen. We get it, cancer creates all sorts of worries and fears, but we have one mouth and two ears for a reason. So, listen (you will get your turn to speak).

Finally, recognize you could lose each other's friendship at some point. Remember, this is cancer and not pink sparkly glitter, rainbows and puppies. But, on a much less dramatic note, you could each simply go back to your own regularly scheduled lives after active cancer treatment ends.

In my case, I have a dear fellow breast cancer friend who was several years out from treatment at the time of my diagnosis and now we remain friends 10 years after my treatment ended! When we get together, we discuss many things but not always cancer. I also had another breast cancer friend, we were basically a support group of two, who I went through active treatment with, and over the years we have gone our separate ways. Though honestly, if either of us reached out, I feel like the other person would be there in a flash.

The bonds that come with a cancer friendship can trump many other connections. It might be because there have been some shared raw and honest moments through cancer treatment. Together, we will get through cancer. I send cyber hugs (hopefully that is still a 'thing') to all of you!

Friends with cancer, even years down the road, understand your ongoing cancer anxieties without needing reminders or a refresher course. We get it.

Cancer Friends ‘Get’ Each Other

Patients with relapsed or refractory follicular lymphoma treated with Kymriah (tisagenlecleucel) – a CAR T-cell therapy – achieved a target complete response rate, according to an interim analysis of the phase 2 ELARA trial.

There were also no new safety concerns observed at interim analysis, according to the agent’s manufacturer, Novartis.

“We are pleased that Kymriah is showing meaningful results and may provide a potentially definitive treatment option for patients with relapsed and refractory follicular lymphoma,” said Novartis’s Chief Medical Officer Dr. John Tsai in a press release.

With this, the trial met its primary endpoint of complete response rate.

The multicenter, single-arm, open-label phase 2 trial is designed to assess the safety and efficacy of Kymriah in adults with relapsed/refractory follicular lymphoma enrolled in more than 30 sites across 12 countries worldwide. The Food and Drug Administration granted a Regenerative Medicine Advanced Therapy designation to Kymriah earlier this year for relapsed/refractory follicular lymphoma based on preliminary results of the ELARA trial.This designation can help expedite the development and review of Kymriah as a regenerative therapy for these patients.

Novartis plans to present these results at an upcoming medical meeting.

“These results further support our efforts to reimagine medicine in this incurable malignancy and reach this underserved patient population, who are historically burdened with several years of various treatments,” Tsai concluded.

“These results further support our efforts to reimagine medicine in this incurable malignancy and reach this underserved patient population, who are historically burdened with several years of various treatments,” said Dr. John Tsai.

Phase 2 Interim Analysis Shows Improved Response in Patients with Follicular Lymphoma

There have been several updates in the field of mantle cell lymphoma over the last several weeks. Here, 

® looks back at some of the latest news and updates affecting patients with that cancer type.


Data from an analysis of approximately 1,200 patients with mantle cell lymphoma (MCL) collected across 12 treatment centers presented at the 2020 ASCO Virtual Scientific Program demonstrated that maintenance Rituxan (rituximab) was associated with 

improved progression-free survival and overall survival

, but an autologous stem cell transplant was not.

Understanding the genetic mutational profile of patients with MCL can be a useful risk-stratification tool in helping to 

best identify appropriate treatment options

The Food and Drug Administration’s (FDA) recent approval of Tecartus (brexucabtagene autoleucel, formerly KTE-X19) for the treatment of adults with relapsed or refractory MCL will 

forever change the way the disease is treated

 with lymphoma, because the options are just really exploding at a very encouraging rate,” said Dr. Lori A. Leslie in a recent interview.

“We now have second and third generation cousins of thalidomide that are very useful. So, lenalidomide in combination with rituximab is an 

effective therapy for mantle cell lymphoma

 that voids some of these adverse events that I’m talking about,” said Dr. Ian Flinn in a recent interview with 

A roundup of the latest news and updates for patients with mantle cell lymphoma from CURE®.

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