Currently Viewing
Cancer-Related Fatigue May Be a Major Symptom in Multiple Myeloma
October 25, 2018 – Kristie L. Kahl
Anti-PD-1 Therapy Shows Potential for Recurrent, Advanced MSI-H Endometrial Cancer
October 24, 2018 – Jessica Skarzynski
Two Types of Mantle Cell Lymphoma: Similar, Yet So Different
October 24, 2018 – Kristie L. Kahl
Joining Forces Against Hereditary Risk for Breast and Ovarian Cancer
October 24, 2018 – Jessica Skarzynski and Kristie L. Kahl
'Bringing Hope Home' After a Cancer Diagnosis
October 23, 2018 – Brielle Urciuoli
Aggressive Radiation Therapy Improves Survival in Patients with Metastatic Cancer
October 23, 2018 – Jessica Skarzynski
Those in Remission from Bladder Cancer Report More Positive Experiences
October 23, 2018 – Kristie L. Kahl
FDA Approves Khapzory Injection
October 23, 2018 – Kristie L. Kahl
New Research Says Universal Lynch Syndrome Testing Should Be Expanded
October 22, 2018 – Jessica Skarzynski

Cancer-Related Fatigue May Be a Major Symptom in Multiple Myeloma

A recent study found that fatigue reported among newly diagnosed patients with multiple myeloma may predict survival outcomes.
BY Kristie L. Kahl
PUBLISHED October 25, 2018
Cancer-relate fatigue may occur more often in patients with multiple myeloma who report with lower functional levels or performance scores, according to study results published in the International Journal of Hematology.

In addition, its incidence may predict poorer survival outcomes among new-diagnosed patients.

Cancer-related fatigue is one of the common non-hematological adverse events in patients with malignancies and affects quality of life negatively,” the researchers wrote. “(Cancer-related fatigue) occurs due to various reasons, such as patient-related factors, treatment-related factors, inflammatory cytokines, and metabolic and/or endocrine dysregulation.”

The development of proteasome inhibitors and immunomodulatory drugs has improved the prognosis of multiple myeloma in the last 10 years; however, these agents may also increase the incidence of viral infections by the herpes family like HHV-6 and HHV-7.

While the reactivation of HHV-6 and HHV-7 may be related to fatigue in healthy individuals, its effect on those with cancer is unknown.

Therefore, the researchers prospectively analyzed the clinical significance of cancer-related fatigue and the cumulative incidence of this side effect and survival among 16 patients with multiple myeloma who were treated with Velcade (bortezomib), Revlimid (lenalidomide) or Thalomid (thalidomide).

Patients were a median of 67 years old and the majority were men. Eleven patients were newly diagnosed and five had relapsed or refractory disease.
 
Cancer-related fatigue at four months occurred in 54.9 percent of patients. Poor Eastern Cooperative Oncology Group (ECOG) performance scores – designed to determine a patient's level of functioning in terms of their ability to care for themselves, daily activity and physical ability – were related to cancer-related fatigue.

In addition, treatment types were not associated with the cancer-related fatigue incidence in patients, nor were the reactivation of HHV-6 and HHV-7.

The researchers found that the overall and progression-free survival among patients with newly-diagnosed multiple myeloma who reported with cancer-related fatigue was significantly shorter than in those without. For example, the two-year overall survival rate was only 20 percent in the fatigued group compared with 100 percent among those without.

“In (newly diagnosed multiple myeloma) patients, fatigue was one of the major symptoms in 32 percent of patients and related to anemia and the other symptoms due to MM,” the researchers wrote. “In addition, fatigue due to treatment was also frequently observed.”

Lastly, the researchers noted that further studies are warranted. “Future studies have been planned to analyze (cancer-related fatigue) related factors including cytokines and reactivation of HHV-6 and HHV-7 in a larger cohort of (newly-diagnosed multiple myeloma).


 
Be the first to discuss this article on CURE's forum. >>
Talk about this article with other patients, caregivers, and advocates in the Myeloma CURE discussion group.

Related Articles

1
×

Sign In

Not a member? Sign up now!
×

Sign Up

Are you a member? Please Log In