Article

Cardiac issues and Avastin

Author(s):

One of the issues for cancer survivors is the long-term and late effects of treatment-- from both radiation and the drugs used. For example, we have known for a long time that doxorubicin (Adriamycin) has cardio toxicity issues, and those who receive this drug need to be monitored. If you received Adriamycin, you had a heart scan before treatment and one after to be sure your heart was not damaged. I visited a cardiologist a number of years ago to get a good cardiac baseline when I was around 20 years out from treatment. I had been followed over the years and no problems had shown up, but I thought it was time.The late effects of radiation are also becoming better known as those who received radiation live long enough to begin exhibiting cardio and muscoskeletal problems. This weekend while attending a conference on Cancer Survivorship for Clinicians put on by Dana-Farber Cancer Institute and Harvard Medical School, I heard of new concerns around Avastin and heart issues. Cancer patients who were treated with VEGF or VSP inhibitors – the drugs that target the angiogenic pathway, need to be followed for cardiology problems because these pathways are also essential in normal cardiac function. The research around renal patients by Javid Moslehi, MD, co-director of the cardio-oncology program at Dana-Farber Cancer Institute, is scheduled for publication, and it follows researched released earlier this year around women with metastatic breast cancer who took the drug.Basically, Moslehi showed increased hypertension, arterial thromboses including myocardial infarction, arrhythmias and heart failure in some patients. So the message is clear. If you have received these drugs, be sure you are being followed for cardiac problems.

Newsletter

Stay up to date on cancer updates, research and education

Related Videos
Waldenstrom macroglobulinemia is often slow growing, with high survival but lower quality of life over time, explained researcher Alisha Kimble.
Image of woman.
Image of two doctors and text.
Combining JNJ-1900 with Keytruda may improve distant control of lung cancer, explained by Dr. Jared Weiss.
image of serzan.
Dr. Breelyn Wilky explains that personalized treatments are helping improve outcomes for patients with gastrointestinal stromal tumors.
Image of two doctors with text.
Image of doctors with text.
Imiage of two doctors with text.
Treatment with zanzalintinib plus Opdivo and Opdualag is an option worth exploring in patients with previously untreated clear cell renal cell carcinoma
Related Content