In Kidney Cancer Treatment, ‘Personalized Biomarkers Work’


Therapies that target specific characteristics on kidney cancer cells are showing promise in the space, an expert explained.

Biomarker-driven therapies work in kidney cancer, and can lead the way for improving outcomes for aggressive disease subtypes, explained Dr. Yasser Ged, co-director of the Kidney Cancer Research Program and assistant professor of Oncology at Johns Hopkins Medicine in Baltimore.

At the 2023 Kidney Cancer Research Summit, Ged discussed findings from the phase 2 ORCHID trial, which evaluated Lynparza (Olaparib) in patients with metastatic kidney cancer that had a BRCA-associated protein 1 (BAP1) or other DNA mutations — a group of patients that typically have aggressive disease, according to Ged.

READ MORE: BAP1-Mutated RCC Responds to Treatment with Lynparza

ORCHID findings showed that among 11 patients whose data was evaluated, two experienced disease control, meaning that their disease shrunk or remained stable, while three had their tumors shrink, highlighting that Lynparza, a PARP inhibitor, may be a promising option for this patient population, Ged said.

“That emphasizes the importance of understanding the biology more, and that the role (about how) you can drive our decisions and how we can actually think about thought new targets for kidney cancer,” Ged said in an interview with CURE®’s sister publication, Oncology Live® at the conference.

According to the American Cancer Society, Lynparza and other PARP inhibitors work by blocking the PARP protein, which helps to repair damaged DNA within cancer cells. BRCA mutations also cause difficulties in repairing cells, so when cancer cells have both a BRCA-related mutation and experience PARP inhibition, they tend to die off.


One of the important takeaways is personalized medicine and personalized biomarkers work because the study is biomarker-driven and biomarker-based. That emphasizes the importance of understanding the biology more, and that the role (about how) you can drive our decisions and how we can actually think about new targets for kidney cancer.

The other important takeaway is that BAP1 mutations are known to be very aggressive mutations and have a potential new strategy using PARP inhibitors in tumors, which have a BAP1 mutation, and that is definitely exciting. We may identify a new target or mechanism of action for BAP1 mutations, including a monotherapy or we can combine it with other agents.

For more news on cancer updates, research and education, don’t forget to subscribe to CURE®’s newsletters here.

Related Videos
Image of a woman with short brown hair and glasses.
Image of a man with brown hair and a suit and tie.
Image of a woman with brown bobbed hair with glasses.
Image of Dr. Minesh Mehta at ASCO 2024.
Image of a woman with blond hai
Image of a man with rectangular glasses and short dark hair.
Image of a man with dark hair wearing a suit with a light blue tie.
Image of a woman with long dark hair.
Jessica McDade, B.S.N., RN, OCN, in an interview with CURE
Related Content