Web Exclusive: Clinical Trials for CUP

A listing of clinical trials for patients with cancers of unknown primary are listed below.

Therapy: Treatment based on molecular profiling assay — paclitaxel, carboplatin, bevacizumab, erlotinib

Cancer: Carcinoma of Unknown Primary

Phase: II

Sponsor/Manufacturer: Sarah Cannon Research Institute/Genentech

Contact information: John D. Hainsworth, MD, 615-329-7274; [email protected]

Avastin (bevacizumab)

Therapy: Cancer: Neuroendocrine Carcinoma

Phase: III

Sponsor/Manufacturer: Southwest Oncology Group, National Cancer Institute

Contact information: James Yao, MD, 713-792-2828; [email protected] or 800-392-1611

Therapy: Taxotere (docetaxel), 5-FU (5-fluorouracil), Platinol (cisplatin)

Cancer: Squamous Cell or Undifferentiated Carcinoma

Phase: II

Sponsor/Manufacturer: M.D. Anderson Cancer Center/Sanofi-Aventis

Contact information: Ehab Y. Hanna, MD, 713-745-2672; [email protected]

Therapy: Xeloda (capecitabine)

Cancer: Solid Tumors and Adenocarcinoma of Unknown Primary

Phase: I/II

Sponsor/Manufacturer: Ohio State University Comprehensive Cancer Center

Contact information: OSU Cancer Clinical Trial Matching Service — 866-627-7616; [email protected]

Therapy: Vectibix (panitumumab)

Cancer: Squamous Cell Carcinoma of the Head and Neck; Undifferentiated Carcinoma; Adenosquamous Cell Carcinoma

Phase: I

Sponsor/Manufacturer: Dana-Farber Cancer Institute; Brigham and Women’s Hospital; Massachusetts General Hospital/Amgen

Contact information: Lori J. Wirth, MD, 617-632-3090; [email protected]

Therapy: Nexavar (sorafenib)

Cancer: Advanced Solid Tumors

Phase: II

Sponsor/Manufacturer: University of California Davis

Contact information: UC Davis Clinical Trials Office — 916-734-3089 or Primo N. Lara, MD, 916-734-3772; [email protected]

Therapy: Stereotactic Body Radiotherapy

Cancer: Spinal Neoplasms

Phase: I/II

Sponsor/Manufacturer: M.D. Anderson Cancer Center

Eric L. Chang, MD, 713-563-2300; [email protected]

Contact information:

Investigators in clinical trials may be individual physicians, researchers at institutions, or pharmaceutical company representatives. The contact information given here was provided by those running these trials and was accurate at the time of publication. If you get a voice mail, leave the pertinent information. For additional trials, go to www.curetoday.com/trialcheck.