Wayne Kuznar

After Surgery, Lonsurf Remains Helpful in Gastric Cancer

March 21, 2019

Overall survival in metastatic gas­tric or gastroesophageal junction cancer improved significantly in patients who received the oral combination chemo­therapy Lonsurf regardless of whether they’d had a gastrectomy.

New Multidrug Regimen Achieves Encouraging Results in Metastatic Pancreatic Cancer

March 18, 2019

The experimental oral anticancer regimen known as SM-88, which com­bines four drugs from different classes, shows promising efficacy and safety with no meaningful toxicity in patients with metastatic pancreatic cancer whose disease worsened despite previous treatment.

BRAF V600E-Mutated Cholangiocarcinoma Responds to Drug Combo

March 15, 2019

Nearly half of patients with a particular type of cholangiocarcinoma responded to a combination of two targeted drugs — Tafinlar (dabrafenib) and Mekinist (trametinib), which together inhibit the growth-signaling proteins BRAF and MEK in patients with different types of rare cancers that carry the BRAF V600E gene mutation.

Immunotherapy After Targeted Drug Shows Promise in Advanced Liver Cancer

March 22, 2018

Treatment with the PD-1 inhibitor Keytruda (pembrolizuumab) elicited promising progression-free survival (PFS) and overall survival (OS) results in patients with advanced hepatocellular carcinoma (HCC) who received previous treatment with Nexavar (sorafenib), according to phase 2 findings.

Individualized Treatment Needed for Relapsed, Refractory Multiple Myeloma

October 10, 2017

Patients with relapsed/refractory multiple myeloma should be given individualized treatment approaches guided by the biology of their disease, frailty of the patient and other comorbidities, said Natalie S. Callander, M.D., who presented on the topic at the NCCN 12th Annual Congress: Hematologic Malignancies in San Francisco, California.

Expert Gives an Overview of New Drugs to Treat AML

October 09, 2017

For the past four decades, there have been few advances in the treatment field of acute myeloid leukemia (AML). However, in the year 2017, there have been four new drugs approved by the FDA to treat the disease, with even more promising agents in the pipeline.

Drug Combination Improves Outcomes for Melanoma Subtype

September 20, 2017

In a recent phase 2 study, nearly half of patients who had resectable stage 3B/C BRAF V600-mutant melanoma achieved pathologic complete response (pCR) – meaning that no active cancer cells are present – with neoadjuvant combination therapy consisting of Tafinlar (dabrafenib) and Mekinist (trametinib).

Immunotherapy Combination Shows Benefit in Phase 2 Advanced Melanoma Trial

April 25, 2016

The combination of Yervoy and Opdivo showed a 42 percent improvement in overall survival compared with Yervoy monotherapy for patients with advanced melanoma in a two-year assessment of the phase 2 CheckMate-069 trial.