An Expert Discusses Nubeqa Side Effects Patients Should Know About

Long-term follow-up from the ARAMIS trial showed that Nubeqa (darolutamide) is not only efficacious in treating patients with nonmetastatic castration-resistant prostate cancer, but the drug also is tolerable, explained Dr. Neal Shore.

In a recent interview at the 2023 American Society of Clinical Oncology Genitourinary Cancers Symposium, Shore, US chief medical officer, Surgery and Oncology, GenesisCare USA, the medical director, Carolina Urologic Research Center, discussed Nubeqa-related side effects that patients may expect and should look out for when starting on the therapy.

READ MORE: Nubeqa Outperforms Xtandi, Erleada in Non-metastatic Castration-resistant Prostate Cancer

Nubeqa works by blocking androgens (male sex hormones) from binding to androgen receptors, and, in doing so, preventing cancer cells from surviving and reproducing.

Transcription

Well, you know, what, particularly with (Nubeqa), and you see this within the class of androgen receptor signaling inhibitors is you can have some more fatigue, you can get some occasional muscular-skeletal discomfort, and the occasional urinary tract infection (or) hot flush.

But in what we've seen in earlier studies, early phase 1 (and) 2 studies, is really a paucity of cognitive impairment. A paucity of depression that we've seen across the class of (androgen-receptor signaling) and particularly cognitive impairment, we haven't seen a high incidence of falls, we haven't seen a particular high incidence of hypertension or cardiovascular effects, and less than 1% incidence of grade 1/2-type rash.

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