Study Initiated for Bispecific Antibody in Patients With T-cell Lymphoma


A phase 1 trial of ONO-4685 was initiated for the evaluation of the antibody in patients with relapsed or refractory t-cell lymphoma.

A phase 1 study from Ono Pharma USA, Inc. will examine the effects of ONO-4685, an anti-PD—1/CD3 bispecific antibody, in patients with relapsed or refractory T-cell lymphoma.

"We are excited to initiate the Phase 1 study of ONO-4685, an anti-PD-1/CD3 bispecific antibody with a novel mechanism of action, and hope that ONO-4685 will provide benefit to the patients with relapsed or refractory T-cell lymphoma in the U.S. one day," said Masahiro Katayama, Executive Vice President and US/EU Head of Clinical Development, at Ono Pharma USA, Inc., in a release.

ONO-4685 binds to PD-1 (an inhibitory receptor expressed on activated T and B cells) and CD3 (a component protein of the T-cell receptor) in the body. It was developed to treat autoimmune diseases and hematologic malignancies and has potential to treat T-cell lymphomas.

The trial will be conducted at multiple sites in the U.S. and is an open label dose escalation study.

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