• Waldenström Macroglobulinemia
  • Melanoma
  • Bladder Cancer
  • Brain Cancer
  • Breast Cancer
  • Childhood Cancers
  • Gastric Cancer
  • Gynecologic Cancer
  • Head & Neck Cancer
  • Immunotherapy
  • Kidney Cancer
  • Leukemia
  • Liver Cancer
  • Lung Cancer
  • Lymphoma Cancer
  • Mesothelioma
  • MPN
  • MDS
  • Myeloma
  • Prostate Cancer
  • Rare Cancers
  • Sarcoma
  • Skin Cancer
  • Testicular Cancer
  • Thyroid Cancer

Targeted Therapies for Advanced MCL May Improve Outcomes as Front-line Treatment


Mantle cell lymphoma remains incurable, despite researchers’ best efforts. However, new treatment options show promise in the relapsed/refractory setting and may improve patient outcomes if moved to the front-line, according to Dr. Reem Karmali.

Mantle cell lymphoma (MCL) is a disease that “unfortunately still remains incurable, despite our best efforts,” according to Dr. Reem Karmali. However, due to the ever-evolving treatment landscape, new therapies are being offered to patients with relapsed and refractory MCL, including BTK inhibitors. Thanks to these targeted therapies, patients with MCL are living much longer and experiencing a better quality of life.

“BTK inhibitors like (Imbruvica [ibrutinib]) and (Calquence [acalabrutinib]) are very active with response rates from 70% to 80% in the relapsed and refractory (MCL) setting,” said Karmali. “The question is whether these agents can be moved up to the front-line setting and improve outcomes in these patients.”

At the 2019 American Society of Clinical Oncology Annual (ASCO) Meeting, she discussed the advancements being made in the treatment landscape, the use of targeted therapies to treat MCL and front-line interventions that could potentially fill the unmet needs of patients with MCL.

Related Videos
Woman with dark brown hair and pink lipstick wearing a light pink blouse with a light brown blazer. Patients should have conversations with their providers about treatments after receiving diagnoses.
Man in a navy suit with a purple tie. Dr. Saby George talks to CURE about how treatment with Opdivo could mitigate disparities in patients with kidney cancer.
Dr. Kim in an interview with CURE
Dr. Barzi in an interview with CURE
Related Content