Video

Targeted Therapies Improve Overall Survival for Patients With Colorectal Cancer Subtype

The cancer landscape has changed for patients with the introduction of targeted therapies, and a combination targeted therapy for some patients with colorectal cancer shows new promise.

Patients with BRAF V600E-mutant colorectal cancer have a very poor prognosis compared to other subtypes of colorectal cancer, but updated results from a three-arm phase 3 study showed promise for the targeted combination therapy of the BRAF and EGFR inhibitors Braftovi (encorafenib) and Erbitux (cetuximab), with or without Mektovi (binimetinib), according to Dr. Scott Kopetz.

Targeted therapies have changed the landscape for many different cancer types and being able to target a subtype like BRAF V600E-mutant colorectal cancer opens pathways that patients may not have had before, as the study showed an improved overall survival period of nine months.

Kopetz, a gastrointestinal oncologist at The University of Texas MD Anderson Cancer Center in Houston, had the chance to sit down with CURE for an interview at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium and discuss how a targeted therapy for this patient population is beneficial to their overall treatment.

TRANSCRIPTION

The data is really looking at, how to optimally treat these patients. We know that patients with a BRAF V600E mutation really should be treated in a different manner than others. This is really showing that aggressive chemotherapy may be effective initially, but the duration of benefit from standard cytotoxic chemotherapy is less than what we see in others.

So, really thinking about how you address targeting the BRAF mutation itself becomes a key part of that. I think importantly, when we think about the this population, as a very distinct entity, as it is both at a biologic level — precursors lesions the polyps for patients with these tumors are very different than the pathways that are activated, carcinogenic pathways are different, and as mentioned, the clinical outcomes are very different for these patients. And those are the reasons that we really think about this as a distinct subgroup of colorectal cancer.

Newsletter

Stay up to date on cancer updates, research and education

Related Videos
Daniel Jernazian, who beat cancer twice, credits his sports mindset for survival and calls it winning his ‘life World Championship’.
Patients in rural or underserved areas may have worse outcomes, highlighting the need for early support to address care access barriers.
Image of man with text.
Dr. Emre Yekedüz discusses how ASCO 2025 highlights precision medicine, biomarkers and the gut microbiome as keys to advancing kidney cancer care.
Dr. Breelyn Wilky stresses the importance of expert guidance and second opinions for patients with GIST, as treatment options continue to evolve rapidly.
Mark Daniels, 83, credits CAR T-cell therapy and compassionate care for helping him overcome lymphoma and endure the isolating treatment toll.
An early study of BGB-16673 for hard-to-treat leukemia found that side effects were manageable with no new safety concerns.
Image of woman with text.
Image of goy, and text.
Watch oncology dietitian Kenisha Parikh prepare creamy lentil soup, a soothing, protein-packed recipe to help ease side effects during treatment.
Related Content