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Combination Improves Responses, Misses Survival Endpoint in Bladder Cancer Trial
April 25th 2018The combination use of Cyramza (ramucirumab) plus docetaxel showed improvements in objective response rate (ORR) and a positive trend in overall survival (OS) among patients with advanced bladder cancer, according to additional results from the phase 3 RANGE trial.
High-Grade Endometrioid Endometrial Cancers Likely to Benefit from Immunotherapy
April 24th 2018Researchers evaluates microsatellite instability-high status, tumor mutation burden and high PD-L1 expression to determine which grade of tumors would benefit from immunotherapy treatment among women with endometrioid endometrial cancer.
FDA Approves First Assay to Identify Rubraca Benefit Among Women with Ovarian Cancer
April 24th 2018The Food and Drug Administration (FDA) approved a next-generation sequencing (NGS) companion diagnostic assay that can detect BRCA1/2 genetic mutations, as well as the percentage of genomic loss of heterozygosity (LOH) in patients with ovarian cancer.
Pre-Surgical Immunotherapy Identifies Potential Benefit, Risk of Recurrence in Melanoma
April 19th 2018For patients with melanoma, administration of a PD-1 checkpoint blockade therapy in the neoadjuvant setting – meaning it was given before the main treatment – could result in improved outcomes and better insight to patient responses.
FDA Grants Opdivo Priority Review for Small Cell Lung Cancer
April 19th 2018The Food and Drug Administration (FDA) granted priority review to a supplemental biologics license application for Opdivo (nivolumab) for the treatment of patients with small cell lung cancer with disease progression following two or more lines of therapy.