Treatment Continues to Advance in Ovarian Cancer and Other Gynecologic Malignancies

With the addition of PARP inhibitors, as well as new agents on the horizon, the treatment landscape of gynecologic cancers is progressing.
There has been major progress in treating gynecologic malignancies in recent years, especially for ovarian cancer, says Douglas A. Levine, M.D.

For example, PARP inhibition has gained impressive traction as a therapeutic option for patients with ovarian cancer. In 2014, Lynparza (olaparib) was approved for the treatment of patients with BRCA-positive advanced ovarian cancer following treatment with three or more prior lines of chemotherapy. Ongoing phase 3 trials are examining the agent as maintenance therapy or an alternative to chemotherapy in women with recurrent disease.

Rucaparib was granted a priority review by the FDA in August 2016 for patients with BRCA-positive advanced ovarian cancer who have received two or more prior lines of chemotherapy. A final decision is expected by Feb. 23, 2017.

And in November 2016, a new drug application to the FDA was completed for niraparib as a maintenance treatment for women with recurrent platinum-sensitive ovarian, fallopian tube or primary peritoneal cancer.

In an interview with CURE at the recent 2016 Chemotherapy Foundation Symposium, Levine, professor, Department of Obstetrics and Gynecology, director, Division of Gynecologic Oncology, NYU Langone Medical Center, discussed these agents and other advances toward precision medicine in the treatment of patients with gynecologic malignances.

Can you provide an overview of your presentation?

When it comes to precision medicine, there are many important aspects that will affect the way we take care of cancer patients. One part of my talk focused on diagnostic dilemmas, because treating the cancer patient really starts with a correct diagnosis, and we partner with our pathologists very closely. The gynecologic pathologist is a very important part of the gynecologic oncology team, and it’s important to have a correct diagnosis to treat somebody. Precision medicine can help us make sure we’re treating the right patient with the right tumor when we use novel molecular diagnostics with traditional pathology. Traditional pathology gets you to the right place, and molecular pathology can then hone in on the diagnosis.

What are some of the immediate next steps to take?

As of now, we have a very exciting class of drugs called PARP inhibitors, and they’re very effective in women who have tumors with a BRCA mutation, but the exciting part now is to figure out what other tumors are going to respond to PARP inhibitors, and how we can combine PARP inhibitors with other agents to make them more broadly available to the oncology community.

What potential combination regimens are emerging with PARP inhibitors?

Combining PARP inhibitors with chemotherapy agents has been a little bit difficult, but we do have an ongoing trial, and we’ll see what that shows. I think in the recurrent setting is where they’re really going to be the most effective, and combining them with immunotherapy, with angiogenic therapy, and with other agents that we can’t even think about today — you know, cell cycle inhibitors, where we can really harness that potential — it’ll be very exciting.

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