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Metastatic Triple Negative Breast Cancer: Overcoming Challenges in Diagnosis Treatment and Management

CURE Connections 

Nour Abahadra, MD, of Memorial Sloan Kettering discusses the diagnosis, treatment, and management of metastatic triple negative breast cancer (TNBC) and patient guest Shay Elkins shares her experience navigating her diagnosis and treatment.

Dr Nour Abahadra of Memorial Sloan Kettering discusses the diagnosis, treatment, and management of metastatic triple negative breast cancer (TNBC). Patient guest, Shay Elkins, shares her experience, from discovering a rapidly growing tumor to navigating her diagnosis and treatment, highlighting the importance of personalized support and resources available online.

Background on Metastatic Triple Negative Breast Cancer

Dr Noor Abuhadra discusses the various first-line treatment options for metastatic TNBC, highlighting the importance of PDL1 expression for immunotherapy and germline testing for targeted therapies like PARP inhibitors. Patient Shay Elkins shares her treatment journey, from her initial chemo and immunotherapy to surgical intervention, emphasizing the importance of a collaborative approach with her healthcare team and the supportive role of nursing staff.

Initial Treatment Options for Metastatic TNBC

Shay Elkins, a patient with triple negative breast cancer, shares her experience of relapse six months post-treatment, eventually leading her to seek a second opinion for her recurring symptoms. Dr. Noor Abuhadra discusses second-line treatment options for metastatic triple negative breast cancer, emphasizing newer therapies like antibody drug conjugates and PARP inhibitors, and highlights the evolving landscape that offers hope for patients.

Second-Line Therapy for Metastatic TNBC

Shay Elkins, a patient with metastatic triple-negative breast cancer, discussed her experience with second-line treatment. Dr. Noor provided insights into the positive outcomes from the ASCENT study.  

ASCENT Study: Impact of Sacituzumab Govitecan on Metastatic TNBC

Dr. Noor Abuhadra discusses managing adverse events in patients receiving TRODELVY (sacituzumab govitecan), a later-line systemic therapy for metastatic triple-negative breast cancer. Shay Elkins, a patient, shares her experience with significant side effects including diarrhea, low white blood cell counts, and hair loss, while Dr. Abuhadra emphasizes the need for proactive management of these issues to maximize treatment time and maintain quality of life. 

Managing Adverse Events in Patients Receiving Later Line Systemic Therapy for Metastatic TNBC

Dr. Noor Abuhadra and patient Shay Elkins discuss overcoming barriers to cancer treatment access and reimbursement. Shay shares her relatively smooth experience with insurance coverage, while Dr. Abuhadra emphasizes that healthcare teams will fight for patient coverage, especially when treatments are backed by research and FDA approval. Dr. Abuhadra also mentions having a financial clearance department to handle denials and secure approvals, as well as training staff to fill out prior authorization forms. Shay underlines the importance of self-advocacy and leveraging online communities for both emotional support and practical advice.

Overcoming Barriers to Treatment Access and Reimbursement

Receiving a cancer diagnosis is life-altering. Although every situation is unique, the emotional experience and need for guidance and support is universal. You will undoubtedly have many questions and concerns. At CURE, we recognize the power of information and community. Our medical experts, patient guests, caregivers, and family members featured on CURE Connections® are here to share their insights based on their own knowledge and experiences.

Second-Line Therapy for Metastatic TNBC

EP: 1.Background on Metastatic Triple Negative Breast Cancer

EP: 2.Initial Treatment Options for Metastatic TNBC

EP: 3.Second-Line Therapy for Metastatic TNBC

EP: 4.ASCENT Study: Impact of Sacituzumab Govitecan on Metastatic TNBC

EP: 5.Managing Adverse Events in Patients Receiving Later Line Systemic Therapy for Metastatic TNBC

EP: 6.Overcoming Barriers to Treatment Access and Reimbursement

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