Premenopausal Breast Cancer May Be Linked to Poor Diet in Adolescence, Young Adulthood

Poor diet in adolescence and early adulthood may increase a woman's chance of developing premenopausal breast cancer, according to the findings of a recent study.
BY KATIE KOSKO @Katie_Kosko
PUBLISHED: MARCH 01, 2017
Poor diet in adolescence and early adulthood may increase a woman’s risk of developing breast cancer before menopause, according to a study recently published in the journal Cancer Epidemiology, Biomarkers & Prevention.
 
Researchers from the UCLA Fielding School of Public Health in Los Angeles, examined the potential effect of a diet associated with chronic inflammation on breast cancer. This kind of a diet consists of little vegetable consumption and is high in sugar-sweetened drinks, diet soft drinks, refined sugars and carbohydrates, red and processed meats, as well as margarine. These foods have all been linked to high levels of inflammatory markers in the blood, said Karin B. Michels, Sc.D., Ph.D., professor and chair of the Department of Epidemiology.
 
“Because breast cancer takes many years to arise, we were curious whether such a diet during the early phases of a woman’s life is a risk factor for breast cancer,” Michels said.
 
She and her colleagues used data from 45,204 women enrolled in the Nurses’ Health Study 2, which began in 1989 to study oral contraceptives, diet and lifestyle risk factors among young nurses (aged 25-42).
 
That study first examined adult diet in 1991 using a food-frequency questionnaire, when the women were between 27 and 44 years old. In 1998, when the women were aged 33 to 52, they completed another food-frequency questionnaire about their diet during high school. The questionnaires continue to be administered at four-year intervals.
 
Researchers in this most recent study concluded that 870 of the women who completed the high school food-frequency questionnaire were diagnosed with premenopausal breast cancer and 490 were diagnosed with postmenopausal breast cancer.
 
Each woman’s diet was given an inflammatory score, using a method that links diet with inflammatory markers in the blood, and the women were then divided into five groups based on their score. Those women in the highest score group for adolescent diet had a 35 percent higher risk for premenopausal breast cancer relative to those in the lowest score group.
 
The same analysis was done based on early adulthood diet, and researchers determined that those in the highest inflammatory score group had a 41 percent higher risk for premenopausal breast cancer relative to those in the lowest score group.



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