Prepping for Treatment
June 19, 2013 – Kathy LaTour
Children Are Not Little Adults
June 19, 2013 – Laura Beil
Autumn Colbert: A Daughter Undaunted
June 19, 2013 – Don Vaughan
The Power of Positive Thinking
June 19, 2013 – Jane Hill
The Health Hypothesis
June 19, 2013 – Jane Hill
Encouraging Words
June 18, 2013 – Don Vaughan
Andropause & Menopause
June 19, 2013 – Barbara Sadick
Treatment Snapshot
June 19, 2013 – Lacey Marlow
Tracking Down Infections
June 19, 2013 – Charlotte Huff
Susie's Story
June 19, 2013 – Kathy LaTour
Robert A. Kyle, MD
June 19, 2013 – Don Vaughan
Qi Gong May Improve Quality of Life in Breast Cancer Patients
June 19, 2013 – Elizabeth Whittington
And in Health: A Guide for Couples Facing Cancer Together
June 19, 2013 – Katherine Lagomarsino
Finding a Clinical Trial Just Got Easier
June 19, 2013 – Jon Garinn
Renewed Focus on Smoking Cessation
June 19, 2013 – Elizabeth Whittington
The National Race to End Women’s Cancer
June 19, 2013 – Jon Garinn
Genetic Variations Found in ALL Patients of Different Ethnicities
June 19, 2013 – Katherine Lagomarsino
Hospitals Need a Menu Makeover
June 19, 2013 – Len Lichtenfeld, MD
Jolie’s Mastectomy Raises Awareness, Prompts Debate
June 19, 2013 – Lindsay Ray
Cancer Clusters and Congress
June 19, 2013 – Lena Huang
ASCO Updates
June 19, 2013 – Staff Reports
Know Your Options
June 19, 2013 – Carol Marcusen
Transcending Cure with Care
June 19, 2013 – Anne Falgoust Ott
Pipeline
June 18, 2013 – Lindsay Ray
Grapefruit Juice: Forbidden Fruit?
June 19, 2013 – Jeanne Erdmann
Up All Night?
June 19, 2013 – Lacey Marlow
Cancer Overtakes Heart Disease As Leading Cause Of Death In Hispanic Population
June 19, 2013 – Roxanne Nelson
Letters From Readers
June 19, 2013
Message From the Editor
June 19, 2013 – Debu Tripathy, MD
Silver Linings in Caregiving
June 19, 2013 – Jane Hill
Managing Expectations
June 18, 2013 – Barbara Sadick
Mind Over Matters
June 19, 2013 – Don Vaughan
Check Please: Choosing the Best Hospital for Your Cancer Surgery
June 18, 2013 – Charlotte Huff
Heart of the Matter: Cardiac Toxicity
June 17, 2013 – Kathy LaTour
Vital Signs: Recognizing and Managing Distress
June 18, 2013 – Laura Beil
Treating Multiple Myeloma From Every Angle
June 18, 2013 – Heather L. Van Epps, PhD
Prepping for Treatment
June 19, 2013 – Kathy LaTour
Children Are Not Little Adults
June 19, 2013 – Laura Beil
Autumn Colbert: A Daughter Undaunted
June 19, 2013 – Don Vaughan
The Power of Positive Thinking
June 19, 2013 – Jane Hill
The Health Hypothesis
June 19, 2013 – Jane Hill
Encouraging Words
June 18, 2013 – Don Vaughan
Andropause & Menopause
June 19, 2013 – Barbara Sadick
Treatment Snapshot
June 19, 2013 – Lacey Marlow
Tracking Down Infections
June 19, 2013 – Charlotte Huff
Susie's Story
June 19, 2013 – Kathy LaTour
Robert A. Kyle, MD
June 19, 2013 – Don Vaughan
Qi Gong May Improve Quality of Life in Breast Cancer Patients
June 19, 2013 – Elizabeth Whittington
And in Health: A Guide for Couples Facing Cancer Together
June 19, 2013 – Katherine Lagomarsino
Finding a Clinical Trial Just Got Easier
June 19, 2013 – Jon Garinn
Renewed Focus on Smoking Cessation
June 19, 2013 – Elizabeth Whittington
The National Race to End Women’s Cancer
June 19, 2013 – Jon Garinn
Currently Viewing
Genetic Variations Found in ALL Patients of Different Ethnicities
June 19, 2013 – Katherine Lagomarsino
Jolie’s Mastectomy Raises Awareness, Prompts Debate
June 19, 2013 – Lindsay Ray
Cancer Clusters and Congress
June 19, 2013 – Lena Huang
ASCO Updates
June 19, 2013 – Staff Reports
Know Your Options
June 19, 2013 – Carol Marcusen
Transcending Cure with Care
June 19, 2013 – Anne Falgoust Ott
Pipeline
June 18, 2013 – Lindsay Ray
Grapefruit Juice: Forbidden Fruit?
June 19, 2013 – Jeanne Erdmann
Up All Night?
June 19, 2013 – Lacey Marlow
Cancer Overtakes Heart Disease As Leading Cause Of Death In Hispanic Population
June 19, 2013 – Roxanne Nelson
Letters From Readers
June 19, 2013
Message From the Editor
June 19, 2013 – Debu Tripathy, MD
Silver Linings in Caregiving
June 19, 2013 – Jane Hill
Managing Expectations
June 18, 2013 – Barbara Sadick
Mind Over Matters
June 19, 2013 – Don Vaughan
Check Please: Choosing the Best Hospital for Your Cancer Surgery
June 18, 2013 – Charlotte Huff
Heart of the Matter: Cardiac Toxicity
June 17, 2013 – Kathy LaTour
Vital Signs: Recognizing and Managing Distress
June 18, 2013 – Laura Beil
Treating Multiple Myeloma From Every Angle
June 18, 2013 – Heather L. Van Epps, PhD

Genetic Variations Found in ALL Patients of Different Ethnicities

A new study pinpoints why Hispanic children are at increased risk of acute lymphoblastic leukemia.

BY Katherine Lagomarsino
PUBLISHED June 19, 2013

For the most part, the increased incidence of acute lymphoblastic leukemia (ALL) among certain ethnic groups and the disease's connection to inherited genes has not been studied in any significant way. To underscore this fact, a recent study led by researchers at St. Jude Children's Research Hospital in Memphis, Tenn., suggested that genome-wide association studies lack diversity, with 96 percent of the subjects participating in the studies being of European descent.

By performing a multi-ethnic study that included 2,450 ALL pediatric patients and 10,977 participants without ALL, St. Jude researchers identified variations in four genes inherited by children that gave them a substantially increased risk of developing ALL, a common childhood cancer of the blood and bone marrow. The research noted that Hispanic children were more likely to inherit two such genes than patients of European or African descent. This genetic variation may explain why Hispanic children are more at risk of developing ALL than children of other ethnic backgrounds.

The study, which was published in a recent online edition of the Journal of the National Cancer Institute, is considered a step forward in understanding the causes of ALL in children.

Be the first to discuss this article on CURE's forum. >>
Talk about this article with other patients, caregivers, and advocates in the General Discussions CURE discussion group.

Related Articles

1
×

Sign In

Not a member? Sign up now!
×

Sign Up

Are you a member? Please Log In