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CLL

Feature Video
Nicole Lamanna, MD, discusses chromosomal abnormalities in chronic lymphocytic leukemia and explains how they play a role when making treatment decisions.
Nicole Lamanna, MD, discusses the significance of the watch-and-wait approach early on in a diagnosis of chronic lymphocytic leukemia.
Nicole Lamanna, MD, explains how levels of red blood cells, white blood cells, and platelets, as well as lymph node involvement, play a role in deciding how to manage chronic lymphocytic leukemia.
Nicole Lamanna, MD, provides an overview of chronic lymphocytic leukemia and explains how it differs from other types of leukemia.
Kristie L. Kahl
The CLL Society is a nonprofit organization that serves the CLL community by offering a platform for patients and caregivers to receive education and support, as well as information on cutting-edge research and treatment options.
Brielle Urciuoli
While patients with chronic lymphocytic leukemia (CLL) tend to have long life expectancies, with many prescribed to a “watch-and-wait” approach, a recent study by the Cancer Support Community (CSC) found that more than half of patients living with the disease reported that having CLL affects their viewpoints regarding their life expectancy.
 
Nitin Jain, M.D.
OVER THE LAST FEW years, significant advances were made in the treatment of patients with chronic lymphocytic leukemia (CLL). Several novel therapies, most of them oral, have now been approved by the Food and Drug Administration. These include Imbruvica (ibrutinib), a Bruton’s tyrosine kinase (BTK) inhibitor; Venclexta (venetoclax), a B-cell lymphoma-2 (BCL2) inhibitor; and Zydelig (idelalisib), a phosphoinositide 3-kinase (PI3K) inhibitor.
Venclexta (venetoclax), a BCL-2 inhibitor, had promising results in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). According to an updated analysis of a clinical trial, the agent led to negative minimal residual disease (MRD) in 40 percent of patients involved.
 
Heather Millar
Researchers are identifying targets to treat chronic lymphocytic leukemia.
Gina Columbus
Imbruvica (ibrutinib) continues to demonstrate benefit in patients with chronic lymphocytic leukemia (CLL) who had at least one prior therapy, according to a four-year follow-up of the RESONATE study, which compared the BTK inhibitor to Arzerra (ofatumumab).
 
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