In the largest study of people with inherited PALB2 mutations to date, the gene was linked to increased lifetime risk of breast cancer in women and men, ovarian and pancreatic cancer but not prostate or colorectal cancer.
In the largest study to date, 524 families with a PALB2 mutation were evaluated for their risk of breast, colorectal, ovarian, pancreatic and prostate cancers. Researchers saw an increased risk of breast cancer in both women and men, as well as increased risk of ovarian and pancreatic cancer. Risk of prostate or colorectal cancer was not increased in people with PALB2 mutations in this study. Knowledge of cancer risk can help people make more informed healthcare decisions. Read more in our XRAY review.