Side Effects Manageable for Newly Approved Folotyn

Vitamin supplementation can reduce certain side effects of Folotyn (pralatrexate), and the majority of patients are able to tolerate the full dose, concluded two safety studies in relapsed or refractory peripheral T-cell lymphoma.

Vitamin supplementation can reduce certain side effects of Folotyn (pralatrexate), and the majority of patients are able to tolerate the full dose, concluded two safety studies in relapsed or refractory peripheral T-cell lymphoma.

One study specifically looked at mucosal inflammation and thrombocytopenia (low platelet counts), two of the most common side effects of the antimetabolite drug Folotyn, and found that it’s appropriate to give patients folic acid and vitamin B12 to minimize these toxic effects.

The second study concluded that two-thirds of patients were able to tolerate the full dose without cumulative side effects. Plus, for patients unable to receive the full dose, reducing their dose by one-third allowed them to continue with therapy.

The Food and Drug Administration approved Folotyn in September, making it the first drug approved in the U.S. for peripheral T-cell lymphoma.