December 12, 2018
December 11, 2018 – Peter Voorhees, M.D.
December 10, 2018 – Matthew Yurgelun, M.D.
December 07, 2018 – William P. Harris, M.D.
December 04, 2018 – Shannon Pulaski
November 30, 2018 – Evan Ruggiero
November 27, 2018 – Maurie Markman, M.D.
November 21, 2018 – Srdan Verstovsek, M.D., Ph.D.
November 19, 2018 – Ghassan K. Abou-Alfa, M.D.
November 16, 2018 – Bill Wimbiscus
November 14, 2018 – John Hopper
October 31, 2018
October 30, 2018
October 29, 2018
October 17, 2018 – Maria Falzone
October 12, 2018
October 10, 2018
October 09, 2018 – Amy Robach
October 05, 2018 – Maggie Row, M.D.
October 04, 2018 – David LeDuc
October 03, 2018 – Leonard Gomella, M.D.
September 27, 2018 – Laura Michaelis, M.D.
September 25, 2018
September 21, 2018 – Tom Weatherall
September 18, 2018 – Thomas K. Weber, M.D., FACS
September 14, 2018 – Patrick Dempsey
September 11, 2018 – Elizabeth Davis, B.S.N., RN, CPN
September 07, 2018 – Bijal D. Shah, M.D.
August 22, 2018 – Dr. Jeff Young
August 21, 2018 – Kathleen Weis, CEO
August 14, 2018 – Andrea J. Wilson
August 10, 2018 – Nancy Bell
August 03, 2018 – Bonnie J. Addario
August 01, 2018 – Christine Stone, MSN, RN, OCN
July 31, 2018 – Ursula A. Matulonis, M.D.
July 26, 2018 – Andre Goy, M.D., M.S.
July 24, 2018 – Sagar Lonial, M.D.
July 18, 2018 – Lori J. Wirth, M.D.
July 16, 2018 – Alicia Latham Schwark, M.D.
July 10, 2018 – Peter Borchmann, M.D.
July 09, 2018 – Michael Wang, M.D.
July 05, 2018 – Matthew R. Cooperberg, M.D., M.P.H.
July 03, 2018 – Taylor Bell Duck
June 27, 2018 – Howard Soule, Ph.D.
June 26, 2018 – David O'Malley, M.D.
June 25, 2018 – Aaron Franke, M.D.
June 21, 2018 – Trine Alma Knudsen, M.D.
June 20, 2018 – Jan Manarite
June 19, 2018 – Sandra Shaw
June 18, 2018 – David Reardon, M.D.
June 14, 2018 – Thomas A. Gallo, MS, MDA
June 12, 2018 – Mike Crosby
June 11, 2018 – H. Jack West, M.D.
June 08, 2018 – Sarah DeBord
June 07, 2018 – Nosayaba Osazuwa-Peters, BDS, MPH, CHES
June 07, 2018 – Terry Fischer
June 06, 2018 – Loretta Williams
June 05, 2018 – Maurie Markman, M.D.
May 30, 2018 – Chloe Spear, BSN, RN, OCN
May 29, 2018 – Gregory L. Beatty, M.D., Ph.D.
May 27, 2018 – Karen DeMairo
May 23, 2018 – Barbara Abernathy, Ph.D.
May 21, 2018 – Ahrang Jung
May 11, 2018 – Dennis R. Scribner, M.D.
April 23, 2018 – Laurel W. Rice, M.D.
April 20, 2018 – Padmanee Sharma, M.D., Ph.D.
April 17, 2018 – Patrick Dempsey
April 10, 2018 – Jeanne M. Palmer, M.D.
April 06, 2018 – Thea's Star of Hope
March 19, 2018 – John Marshall, M.D.
March 15, 2018 – William J Gradishar, M.D.
March 14, 2018 – Jane N. Winter, M.D.
March 13, 2018 – Jarushka Naidoo, MBBCh
March 12, 2018 – Sagar Lonial, M.D.
March 09, 2018 – John Marshall, M.D.
March 07, 2018 – Ruben Mesa, M.D.
February 26, 2018 – Joshua Bauml, M.D.
January 30, 2018 – William G. Wierda, M.D., Ph.D.
January 26, 2018 – Joshua Richter, M.D.
January 23, 2018 – Michael J. Overman, M.D.
January 22, 2018 – Tom Stockwell
January 21, 2018 – Radhakrishnan Ramchandren, M.D.
January 19, 2018 – Marina Chiara Garassino, M.D.
January 19, 2018 – Carole Brennan Miller, M.D.
January 17, 2018 – Julie R. Libon
Currently Viewing
January 15, 2018 – Cristiana Sessa, M.D.
January 13, 2018 – Susan Leclair, Ph.D., CLS (NCA)
January 12, 2018 – Catriona Jamieson, M.D., Ph.D.
January 10, 2018 – Luis A. Diaz, M.D.
January 09, 2018 – Mark Heaney, M.D., Ph.D.
January 08, 2018 – Catriona Jamieson, M.D., Ph.D.
January 06, 2018 – Gabriela Hobbs, M.D.
January 05, 2018 – Lindsey M. Lyle, M.S.
January 04, 2018 – Barbara Abernathy, Ph.D.
January 03, 2018 – Martha Raymond
December 21, 2017 – Julie Nangia, M.D.
December 19, 2017 – David R. Gandara, M.D
December 18, 2017 – Oliver Dorigo, M.D., Ph.D.
December 13, 2017 – Halle Moore, M.D.
December 11, 2017 – Oliver Dorigo, M.D., Ph.D.
December 06, 2017
November 28, 2017 – Anya Khomenko
November 16, 2017 – Michael Krychman, M.D.
November 15, 2017 – Jim Kelly
November 14, 2017 – Ghassan K. Abou-Alfa, M.D.
November 02, 2017 – Thomas Butler, M.D.
November 01, 2017 – Edward S. Kim, M.D.
October 30, 2017 – Ashley Johnson
October 27, 2017 – Mellisa Wheeler
October 26, 2017 – Janine Overcash, Ph.D.
October 25, 2017 – Nadine Barrett, Ph.D.
October 13, 2017 – David Reardon, M.D.
October 11, 2017 – Renata Marie Vestevich
October 05, 2017 – Rebecca Arend, M.D.
October 04, 2017 – Garett Frampton
October 03, 2017 – Gary Rodin, M.D.
October 02, 2017 – Yania Jansen
September 27, 2017 – David Reardon, M.D.
September 19, 2017 – Jeffrey Weber, M.D., Ph.D.
September 15, 2017 – Renee Cowan
September 13, 2017 – Michael D. Becker
September 11, 2017 – Kathryn Burn
September 08, 2017 – Andrea J. Wilson
September 07, 2017 – Martin D. Berger, M.D.
September 07, 2017 – Gary A. Puckrein, Ph.D.
September 06, 2017 – Lauren Belive
September 05, 2017 – Kathleen Gallagher
September 01, 2017 – Beth Meagher
August 31, 2017 – Lisa Richardson, M.D., M.P.H.
August 30, 2017 – Patricia J. Goldsmith
August 29, 2017 – Jeff Allen
August 28, 2017 – Elizabeth Jaffee, M.D.
August 21, 2017 – Donna Cryer
August 16, 2017 – Syed Jafri, M.D.
August 15, 2017 – Richard Boulay, M.D.
July 27, 2017 – Jeffrey Holzbeierlein, M.D.
July 27, 2017 – Johnathan E. Rosenberg, M.D.
July 27, 2017 – Chris Draft
July 26, 2017 – Ramy Ibrahim, M.D.
July 25, 2017 – Sandra Allen-Bard
July 24, 2017 – Fay J. Hlubocky, Ph.D., M.A.
July 17, 2017 – Greg Simon
July 14, 2017 – Mindy Mintz Mordecai
July 07, 2017 – Rami S. Komrokji, M.D.
July 06, 2017 – Axel Hoos, M.D., Ph.D.
July 06, 2017 – Juergen Klenk
June 29, 2017 – Carolyn R. Aldige
June 28, 2017 – Irene Hutchins, M.D., and her patient Steve Valentine,
June 27, 2017 – Patrick Dempsey
June 23, 2017 – Len Lichtenfeld, M.D.
June 21, 2017 – Joseph Greer, Ph.D.
May 30, 2017 – Patrick Dempsey
March 09, 2017 – Jim Kelly
February 22, 2017
February 03, 2017 – Jim Kelly
January 31, 2017 – Jim Kelly
January 18, 2017 – Andrew Schorr
January 12, 2017 – Ross L. Levine, M.D.
January 11, 2017 – Elliott Winton, M.D.
January 09, 2017 – Patricia K. Koenig
January 06, 2017 – Alicia Staley
January 05, 2017 – Moving Mountains for Multiple Myeloma
January 05, 2017 – Dellann Elliott Mydland
January 04, 2017 – Erin H. Blackwell
December 30, 2016 – Fran Drescher
December 29, 2016 – Bonnie J. Blankert
December 28, 2016 – Sam Smith
December 28, 2016
December 23, 2016 – Gary Mervis
December 21, 2016 – Ann Brazeau
December 14, 2016 – Sumul Raval, M.D.
December 12, 2016 – Siddhartha Mukherjee, M.D., Ph.D.
December 02, 2016 – Christian M. Capitini, M.D.
November 29, 2016 – Ann Culkin, R.N., O.C.N.
November 28, 2016 – Beth Sandy, C.R.N.P
November 23, 2016 – Halle Moore, M.D.
November 21, 2016 – Grant Williams, M.D.
November 17, 2016 – Jennifer Klemp, Ph.D., M.P.H.
November 14, 2016 – Gary Shelton, Ph.D.
November 11, 2016 – Chuck Wakefield
November 02, 2016
November 02, 2016
October 21, 2016
October 19, 2016 – Raghav Sundar, M.B.B.S., M.R.C.P., M.Med.
October 05, 2016 – Winson Cheung, M.D.
September 30, 2016 – Matthew Galsky, M.D.
September 29, 2016 – Mark Malkin, M.D.
September 08, 2016 – Yuhong Dong, M.D., PhD
August 31, 2016 – Nathalie LeVasseur
August 30, 2016 – Eric Gelber
August 24, 2016 – Ishwaria Mohan Subbiah
August 23, 2016 – Supriya Mohile
August 19, 2016 – Yvonne Saenger, MD
August 16, 2016 – Ricardo J. Bello
August 12, 2016 – Luke Peppone
August 11, 2016 – Halle Moore
August 08, 2016 – Ronald Natale
August 04, 2016 – Karuppiah Kannan
August 03, 2016 – Claire Friedman, MD
August 02, 2016 – Janet Freeman-Daily
July 29, 2016 – Karuppiah Kannan
July 27, 2016 – Kelly Kenzik, MS, PhD
July 27, 2016 – Barbara Van Husen
July 25, 2016 – Moaath K. Mustafa Ali, MD
July 22, 2016 – Multiple Myeloma Heroes
July 21, 2016 – CURE staff
July 21, 2016 – Emily Johnston, MD
July 20, 2016 – Charles Kamen
July 12, 2016 – Extraordinary Healer
July 07, 2016 – Beth DuPree, MD, FACS, ABIHM
June 27, 2016 – Jennifer Arnold
June 23, 2016 – Greg Cantwell
June 21, 2016 – Carmi Fazio, RN, MSN, ONA
June 15, 2016 – DIANA GORDON, RN, MSN, CPNP, CPON
June 10, 2016 – Lee Schwartzberg, MD, FACP
June 07, 2016 – Carmi Fazio, RN, MSN, ONA
June 07, 2016 – Celestia S. Higano
June 05, 2016 – Nathalie Le Vasseur
June 04, 2016 – Uri Goldberg, MD
June 03, 2016 – Lynne Malestic, RN
June 02, 2016 – Marty Murphy
June 01, 2016 – DIANA GORDON, RN, MSN, CPNP, CPON
May 25, 2016 – Carmi Fazio, RN, MSN, ONA
May 09, 2016 – Diana Gordon, RN, MSN, CPNP, CPON
May 04, 2016 – Lynne Joy Malestic, RN
May 02, 2016 – Eric Stonestreet
April 06, 2016 – Rafat Abonour
April 06, 2016 – Mary Bohn
April 06, 2016 – Alicia O'Neill, Multiple Myeloma Research Foundation
April 06, 2016 – Jenny Ahlstrom
April 05, 2016 – Chuck Wakefield
April 05, 2016 – Ryan Cohlhepp
April 04, 2016 – Jeff Goad
April 04, 2016 – Stan Wagner, Multiple Myeloma Hero
April 01, 2016 – Sponsored Content
April 01, 2016 – Jason Katz
March 31, 2016 – Bob Dickey, Multiple Myeloma Hero
March 24, 2016 – Marlee Matlin
March 23, 2016 – Susan Melvin Hill
March 22, 2016 – Jason R. Gotlib
March 18, 2016 – Kareem Abdul-Jabbar
March 18, 2016 – David Dubin
March 14, 2016 – Amy Robach
February 29, 2016 – David Dubin
February 25, 2016 – Maurie Markman and Vincent T. DeVita
February 25, 2016 – Maurie Markman and Vincent T. DeVita
February 25, 2016 – Maurie Markman and Vincent T. DeVita
February 25, 2016 – Maurie Markman and Vincent T. DeVita
January 29, 2016 – Danielle Novetsky Friedman
January 28, 2016 – Kevin C. Oeffinger
January 25, 2016 – Danielle Nicosia
January 16, 2016 – Mary McCabe
January 12, 2016 – Jessica Safran
January 06, 2016 – Kay Verble
December 23, 2015 – Karen Duffy
December 22, 2015 – Greg Cantwell
December 22, 2015 – Jason R. Gotlib
December 22, 2015 – David T. Boule
December 21, 2015 – Sherry Fox
December 21, 2015 – Santosh Kesari
December 21, 2015 – Rebecca N. Claassen
December 21, 2015 – Susan Melvin Hill
December 21, 2015 – Barbara Van Husen
December 21, 2015 – David Allen Denny
December 18, 2015 – Consumer Affairs
December 09, 2015 – Blake A. Morrison
December 08, 2015 – Jennifer Arnold
December 01, 2015 – Valerie Harper
November 30, 2015 – William G. Wierda
November 30, 2015 – Mark R. Gilbert
November 18, 2015 – Michael J. Mauro
November 18, 2015 – Michael J. Mauro
November 09, 2015 – C. Ola Landgren
November 09, 2015 – C. Ola Landgren
October 27, 2015 – Alison Morris
October 27, 2015 – Alison Morris
October 20, 2015 – David Liu
October 19, 2015 – Rudolph Navari
October 07, 2015 – Christian J. Nelson
October 07, 2015 – Christian J. Nelson
October 06, 2015 – Amanda L. Kong
October 06, 2015 – Amanda L. Kong
October 02, 2015 – Carolyn Presley
October 02, 2015 – Carolyn Presley
September 30, 2015 – Aziz Nazha
September 30, 2015 – Aziz Nazha
September 29, 2015 – Bethany Andrews Rhoten
September 29, 2015 – Bethany Andrews Rhoten
September 28, 2015 – Andrew M. Kaunitz
September 28, 2015 – Andrew M. Kaunitz
September 25, 2015 – Anees B. Chagpar
September 25, 2015 – Anees B. Chagpar
September 24, 2015 – Lecia V. Sequist
September 24, 2015 – Lecia V. Sequist
September 23, 2015 – Sharon L. Bober
September 23, 2015 – Sharon L. Bober
September 22, 2015 – Shaji Kumar
September 22, 2015 – Shaji Kumar
September 21, 2015 – Marianne Davies
September 18, 2015 – Sara M. Tolaney
September 16, 2015 – Ginny Finn
September 15, 2015 – Jacquelyn Powers
September 15, 2015 – Jacquelyn Powers
September 14, 2015 – Gregory J. Riely
September 14, 2015 – Gregory J. Riely
September 11, 2015 – Kim Statham Ringen
September 11, 2015 – Kim Statham Ringen
September 04, 2015 – Debra Patt
September 04, 2015 – Debra Patt
September 03, 2015 – Fred R. Hirsch
September 03, 2015 – Bonnie J. Addario
September 02, 2015 – Susan Krigel
September 02, 2015 – Susan Krigel
September 01, 2015 – Michelle Esser
August 31, 2015 – Anjee Davis
August 28, 2015 – Jill Stopfer
August 28, 2015 – Jill Stopfer
August 27, 2015 – Jessica Ryan
August 27, 2015 – Jessica Ryan
August 26, 2015 – Susan Thornton
August 25, 2015 – Gwendolyn P. Quinn
August 25, 2015 – Gwendolyn P. Quinn
August 24, 2015 – D. Ross Camidge
August 24, 2015 – D. Ross Camidge
August 21, 2015 – Suresh S. Ramalingam
August 21, 2015 – Suresh S. Ramalingam
August 19, 2015 – Mary B. Daly
August 18, 2015 – Hope S. Rugo
August 18, 2015 – Hope S. Rugo
August 17, 2015 – Heidi Gottlieb
August 11, 2015 – Leslie R. Schover
August 11, 2015 – Leslie R. Schover
August 10, 2015 – Frederic C. Kass
August 10, 2015 – Frederic C. Kass
August 03, 2015 – Cokie Roberts
August 03, 2015 – Cokie Roberts
July 30, 2015 – Bonnie J. Addario
July 28, 2015 – Melinda Liggett Irwin
July 28, 2015 – Melinda Liggett Irwin
July 27, 2015 – Janet Freeman-Daily
July 27, 2015 – Janet Freeman-Daily
July 24, 2015 – Paul B. Jacobsen
July 24, 2015 – Paul B. Jacobsen
July 23, 2015 – Bill Aron
July 23, 2015 – Bill Aron
July 22, 2015 – Patrick I. Borgen
July 22, 2015 – Patrick I. Borgen
July 21, 2015 – Kristen Harris
July 21, 2015 – Adele Croteau
July 20, 2015 – Jyoti D. Patel
July 20, 2015 – Jyoti D. Patel
July 10, 2015 – Kara Maxwell
July 10, 2015 – Kara Maxwell
July 10, 2015 – Rep. Frank Pallone Jr.
July 09, 2015 – Rep. Frank Pallone Jr.
July 08, 2015 – Anya Prince
July 08, 2015 – Anya Prince
July 08, 2015 – Anya Prince
July 08, 2015 – Anya Prince
July 07, 2015 – Kenneth Freundlich
July 07, 2015 – Kenneth Freundlich
July 06, 2015 – Rebecca Sutphen
July 06, 2015 – Rebecca Sutphen
July 02, 2015 – Dana Bushman
July 02, 2015 – Dana Bushman
July 01, 2015 – Jennifer Klemp, PhD, MPH
July 01, 2015 – Jennifer Klemp, PhD, MPH
July 01, 2015 – Jennifer Klemp, PhD, MPH
June 30, 2015 – Sue Friedman
June 30, 2015 – Sue Friedman
June 29, 2015 – Melanie A. Nix
June 17, 2015 – Dellann Elliott Mydland
June 11, 2015 – Debu Tripathy
June 10, 2015 – Rep. Frank Pallone Jr.
May 29, 2015 – Colleen M. O'Leary, RN, MSN, AOCNS
May 18, 2015 – Patricia Carter, PhD, RN, CNS
May 15, 2015 – Julie Fleshman
May 13, 2015 – Jeannie Woith, BSN, RN, LMT
May 12, 2015 – Neal D. Shore, MD, FACS
May 08, 2015 – Anne Katz, RN, PhD
May 06, 2015 – Michael Ferraro
May 01, 2015 – Jasmine Martin
April 30, 2015 – Sandra Spoelstra, PhD, RN
April 29, 2015 – Amanda Yopp, NP
April 24, 2015
April 21, 2015
April 17, 2015
April 16, 2015
April 13, 2015
April 13, 2015
April 09, 2015
April 08, 2015
March 30, 2015
March 25, 2015
March 23, 2015
March 20, 2015
March 18, 2015
March 13, 2015
March 11, 2015
February 28, 2015
February 28, 2015
February 19, 2015
February 18, 2015
February 13, 2015
February 11, 2015
February 10, 2015
February 04, 2015
February 02, 2015
January 30, 2015
January 26, 2015
January 23, 2015
January 14, 2015
January 12, 2015
December 11, 2014
December 11, 2014
December 10, 2014
December 06, 2014
December 06, 2014
December 05, 2014
November 13, 2014
October 31, 2014
October 31, 2014
October 01, 2014
October 01, 2014
The Evolution of PARP Inhibitors in Ovarian Cancer
Cristiana Sessa, M.D., of the Oncology Institute of Southern Switzerland, discusses the evolution of how PARP inhibitors are used to treat ovarian cancer.
BY Cristiana Sessa, M.D.
PUBLISHED January 15, 2018
Christiana Sessa, M.D., head of Phase 1-2 Unit and Pharmacology, vice head of Medical Oncology and Head of Clinical Research, Oncology Institute of Southern Switzerland, discusses the evolution of how PARP inhibitors are used to treat ovarian cancer.
Initially, PARP inhibitors were used only in patients who had BRCA1/BRCA2 mutations. However, they then showed activity in patients with high-grade serous ovarian cancer, and in those with what Sessa calls “genomic scarring,” meaning they have DNA damage that cannot be repaired.
Currently there, are three FDA-approved PARP inhibitors in the ovarian cancer space: Lynparza (olaparib), Zejula (niraparib) and Rubraca (rucaparib).
Talk about this article with other patients, caregivers, and advocates in the Ovarian Cancer CURE discussion group.