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Firstline Kadcyla Results Disappointing in HER2-Positive Metastatic Breast Cancer Trial
December 19th 2014Two HER2-targeting regimens anchored by Kadcyla (T-DM1) failed to outperform the standard strategy of Herceptin plus chemotherapy in women newly diagnosed with advanced HER2-positive breast cancer.
Subtype of Triple-Negative Breast Cancer Responds to Neoadjuvant Avastin
December 18th 2014The addition of Avastin (bevacizumab) to standard neoadjuvant chemotherapy significantly improved pathologic complete response rates in women with basal-like breast cancer compared with non-basal-like subtypes.
Somatuline Depot Approved for Gastroenteropancreatic Neuroendocrine Tumors
December 17th 2014The Food and Drug Administration has approved Somatuline Depot (lanreotide) for the treatment of patients with unresectable, well or moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs), based on findings from the phase 3 CLARINET study.
Upfront Faslodex Improves Survival Over Anastrozole in Estrogen-Positive Metastatic Breast Cancer
December 17th 2014Faslodex (fulvestrant) improved overall survival by nearly six months compared with anastrozole as initial hormone therapy for postmenopausal women with estrogen receptor-positive advanced breast cancer, according to findings from the phase 2 FIRST trial.
Keytruda Produces Antitumor Responses in Triple-Negative Breast Cancer
December 12th 2014The PD-1 inhibitor Keytruda (pembrolizumab) has demonstrated promising clinical activity with an acceptable safety profile in heavily pretreated patients with recurrent metastatic triple-negative breast cancer (TNBC).
Abraxane Wins Neoadjuvant Taxane Battle in Breast Cancer Trial
December 11th 2014Abraxane (nab-paclitaxel) proved markedly more effective than conventional paclitaxel as part of a neoadjuvant regimen for patients with high-risk, early breast cancer, according to results presented at the 2014 San Antonio Breast Cancer Symposium.
Early Phase Study Finds PI3K Inhibitor Pictilisib Helps a Subset of Advanced Breast Cancer Patients
December 11th 2014The addition of the investigational PI3K inhibitor pictilisib to the aromatase inhibitor Faslodex in patients with metastatic breast cancer yielded some intriguing findings in the FERGI study.
Chemo Alone May Be Optimal for Some HER2-Positive Breast Cancer Patients
December 11th 2014Research presented at the 2014 San Antonio Breast Cancer Symposium shows that high levels of lymphocytes, white blood cells found in the immune system, could help identify women with HER2-positive breast cancer who could forego chemotherapy.
Childhood Lymphoma Patients and Their Doctors Must Anticipate Late Effects of Treatment
December 11th 2014Researchers gathered at the annual meeting of the American Society of Hematology to learn about survivorship issues and the late effects their patients encounter years, even decades, after therapy.
Tasigna Shows Efficacy for Elderly Patients With Philadelphia-Positive ALL
December 9th 2014Tasigna in combination with chemotherapy elicited a complete hematological remissions (CHR) in 87 percent of elderly patients with newly diagnosed Philadelphia-positive acute lymphoblastic leukemia (Ph-positive ALL).
Adcetris Delivers Post-Transplant Benefit in Relapsed Hodgkin Lymphoma
December 9th 2014Following treatment with high-dose chemotherapy and stem cell transplant, patients with relapsed and difficult-to-treat Hodgkin lymphoma who received Adcetris had a higher likelihood of progression-free survival at two years.