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Testicular Cancer Survivors at Risk of Late Effects of Chemotherapy

“Since effective cisplatin-based chemotherapy was introduced in the 1970s, the overall age-adjusted five-year relative survival rate is 95 percent, and survivors remain at risk for decades for the late effects of cancer and its treatment,” the study authors wrote.
BY Katie Kosko
PUBLISHED August 27, 2018
TREATMENT-RELATED SIDE EFFECTS — even after many years — can be a concern for men who receieved platinum-based chemotherapy for testicular cancer.

A study published in the Journal of Clinical Oncology involved 1,214 survivors who were age 55 or younger at diagnosis and had been finished with first-line chemotherapy for at least a year. The participants completed a comprehensive questionnaire and underwent a physical examination, which revealed the most common negative health outcomes following treatment: obesity, sensory neuropathy, tinnitus (ringing in the ears) and hearing damage. About 5 percent of patients experienced no negative health effects.

The researchers also found that late effects can occur in clusters — for instance, hearing loss or damage and tinnitus; hypertension and diabetes; cardiovascular and related conditions; thyroid disease and erectile dysfunction; and depression or anxiety and diminished functional activity of the gonads.

“Since effective cisplatin-based chemotherapy was introduced in the 1970s, the overall age-adjusted five-year relative survival rate is 95 percent, and survivors remain at risk for decades for the late effects of cancer and its treatment,” the study authors wrote.
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